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Cited 3 time in webofscience Cited 5 time in scopus
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Assessment of hair cell damage and developmental toxicity after fine particulate matter 2.5 mu m (PM 2.5) exposure using zebrafish (Danio rerio) models

Authors
Rhee, JihyeHan, EunjungNam, Kuk JinLim, Kang HyeonRah, Yoon ChanPark, SaemiKoun, SoonilPark, Hae-ChulChoi, June
Issue Date
Nov-2019
Publisher
Elsevier BV
Keywords
Particulate matter; Zebrafish; Hair cell; Toxicity
Citation
International Journal of Pediatric Otorhinolaryngology, v.126
Indexed
SCI
SCIE
SCOPUS
Journal Title
International Journal of Pediatric Otorhinolaryngology
Volume
126
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1475
DOI
10.1016/j.ijporl.2019.109611
ISSN
0165-5876
1872-8464
Abstract
Objectives Particulate matter (PM) exposure has become one of the most serious problems. The aim of the present study was to evaluate the hair cell damage and possible developmental toxicity caused by PM2.5 exposure using a zebrafish model. Methods Zebrafish embryos were exposed to various concentrations of PM2.5. Developmental toxicity was evaluated based on general morphology score (GMS) system and Panzica-Kelly score, and by measurement of body length and heart rate. To evaluate hair cell damage, the average number of total hair cells within four neuromasts exposed to various concentrations of PM2.5 was compared with that of the control group. Results Morphological abnormalities evaluated by the GMS system and Panzica-Kelly score were rare and body length tended to be shorter in the PM2.5-exposed groups. Heart rate decreased significantly in the PM2.5-exposed group. Additionally, significant hair cell damage was observed after PM2.5 exposure. It was dose-dependent and more severe after a longer period exposure (10 dpf). Conclusions In zebrafish embryos, exposure of PM2.5 in the early stages of life decreased heart rate and caused significant hair cell damage in a dose-dependent manner.
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3. Graduate School > Biomedical Research Center > 1. Journal Articles
4. Research institute > Zebrafish Translational Medical Research Center > 1. Journal Articles
2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles

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Rah, Yoon Chan
Ansan Hospital (Department of Otorhinolaryngology-Head and Neck Surgery, Ansan Hospital)
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