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Transforming growth factor-beta 1 and major depressive disorder with and without attempted suicide: Preliminary study

Authors
Lee, Hwa-YoungKim, Yong-Ku
Issue Date
30-Jun-2010
Publisher
ELSEVIER IRELAND LTD
Keywords
Polymorphism
Citation
PSYCHIATRY RESEARCH, v.178, no.1, pp.92 - 96
Indexed
SCIE
SSCI
AHCI
SCOPUS
Journal Title
PSYCHIATRY RESEARCH
Volume
178
Number
1
Start Page
92
End Page
96
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14761
DOI
10.1016/j.psychres.2009.03.023
ISSN
0165-1781
Abstract
A substantial body of evidence indicates that dysregulation of the immune system is associated with suicidal behavior in major depressive disorder (MDD). Transforming growth factor (TGF)-beta 1 is believed to be an important factor in regulating inflammatory responses and to have anti-inflammatory effects. We aimed to identify the role of TGF-beta 1 on suicidal depression. The TGF-beta 1 polymorphisms at codons 10 and 25 were analyzed in 122 suicidal MDD patients, 61 non-suicidal MDD patients, and 120 control subjects and, among them, in vitro TGF-beta 1 productions were measured in 48 suicidal MOD patients, 47 non-suicidal MOD patients, and 91 control subjects. There was no genetic polymorphism at codon 25 and three genotypes at codon 10. No significant difference in the distributions of the TGF-beta 1 genotypes was found among the three groups. The in vitro TCF-beta 1 productions were significantly higher in suicidal MDD patients (844.3 +/- 329.7 pg/ml) and in non-suicidal MOD patients (853.0 +/- 439.7 pg/ml) than in controls (683.0 +/- 397.0 pg/ml) (P=0.01). In vitro TGF-beta 1 productions were not significantly different among patients with any of the TGF-beta 1 alleles or genotypes. Our findings suggest that in vitro TGF-beta 1 productions play an important role on MDD, but we found no associations between TGF-beta 1 and suicidal behavior. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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Kim, Yong Ku
안산병원 (Department of Psychiatry, Ansan Hospital)
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