Detailed Information

Cited 6 time in webofscience Cited 6 time in scopus
Metadata Downloads

Loss of hsp70.1 Decreases Functional Motor Recovery after Spinal Cord Injury in Mice

Authors
Kim, Hyun JeongJung, Ji-InKim, YoungkyungLee, Jae-SeonYoon, Young WookKim, Junesun
Issue Date
Jun-2010
Publisher
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Keywords
Spinal cord injury; Neuroprotection; Heat shock protein; Mice
Citation
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.14, no.3, pp 157 - 161
Pages
5
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Volume
14
Number
3
Start Page
157
End Page
161
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14807
DOI
10.4196/kjpp.2010.14.3.157
ISSN
1226-4512
2093-3827
Abstract
Heat shock proteins (HSPs) are specifically induced by various forms of stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful insults. However, the functional role of Hsp70 in motor function after spinal cord injury (SCI) is still unclear. To study the role of hsp70.1 in motor recovery following SCI, we assessed locomotor function in hsp70.1 knockout (KO) mice and their wild-type (WT) mice via the Basso, Beattie and Bresnahan (BBB) locomotor rating scale, before and after spinal hemisection at T13 level. We also examined lesion size in the spinal cord using Luxol fast blue/cresyl violet staining. One day after injury, KO and WT mice showed no significant difference in the motor function due to complete paralysis following spinal hemisection. However, when it compared to WT mice, KO mice had significantly delayed and decreased functional outcomes from 4 days up to 21 days after SCI. KO mice also showed significantly greater lesion size in the spinal cord than WT mice showed at 21 days after spinal hemisection. These results suggest that Hsp70 has a protective effect against traumatic SCI and the manipulation of the hsp70.1 gene may help improve the recovery of motor function, thereby enhancing neuroprotection after SCI.
Files in This Item
There are no files associated with this item.
Appears in
Collections
1. Basic Science > Department of Physiology > 1. Journal Articles
4. Research institute > Neuroscience Research Institute > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Young kyung photo

Kim, Young kyung
Others (Medical Science Research Management Center)
Read more

Altmetrics

Total Views & Downloads

BROWSE