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Cited 15 time in webofscience Cited 12 time in scopus
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Prolonged Administration Enhances the Renoprotective Effect of Pentoxifylline via Anti-Inflammatory Activity in Streptozotocin-Induced Diabetic Nephropathy

Authors
Han, Kum HyunHan, Sang YoubKim, Han SeongKang, Young SunCha, Dae Ryong
Issue Date
Jun-2010
Publisher
SPRINGER/PLENUM PUBLISHERS
Keywords
diabetic nephropathy; inflammation; pentoxifylline
Citation
INFLAMMATION, v.33, no.3, pp.137 - 143
Indexed
SCIE
SCOPUS
Journal Title
INFLAMMATION
Volume
33
Number
3
Start Page
137
End Page
143
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14835
DOI
10.1007/s10753-009-9167-6
ISSN
0360-3997
Abstract
The beneficial effects of pentoxifylline (PTX), which has an anti-inflammatory and renoprotective effect in diabetic nephropathy, are not completely understood. This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltration of ED-1 positive cells at 4 weeks. Further, in diabetic rats, administration of PTX for 4 weeks inhibited the renal inflammatory reaction, and when administration for 8 weeks, it prevented proteinuria. These findings support the hypothesis that prolonged administration enhances the protective effects of PTX.
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Kang, Young Sun
Ansan Hospital (Department of Nephrology and Hypertension, Ansan Hospital)
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