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Cited 13 time in webofscience Cited 15 time in scopus
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Periodic Variation and Its Effect on Management and Prognosis of Korean Patients With Acute Myocardial Infarction

Authors
Park, Hyo EunKoo, Bon KwonLee, WonjaeCho, YoungjinPark, Jin SikChoi, Ji YongJeong, Myung HoKim, Jong HyunChae, Shung ChullKim, Young JoNam, Chang WookLee, Jae HwanChoi, Dong HoonHong, Taek JongChae, Jei KeonRhew, Jae YoungKim, Kee SikKim, Hyo SooOh, Byung HeePark, Young BaeKAMIR Investigators
Issue Date
May-2010
Publisher
JAPANESE CIRCULATION SOC
Keywords
Acute myocardial infarction; Circadian variation; Periodic variation
Citation
CIRCULATION JOURNAL, v.74, no.5, pp 970 - 976
Pages
7
Indexed
SCI
SCIE
SCOPUS
Journal Title
CIRCULATION JOURNAL
Volume
74
Number
5
Start Page
970
End Page
976
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14879
DOI
10.1253/circj.CJ-09-0344
ISSN
1346-9843
1347-4820
Abstract
Background: The characteristics of the periodic variation in acute myocardial infarction (AMI) and the subsequent effect on management and prognosis have not been fully investigated in a large number of Asian populations. Methods and Results: From a prospective, observational multicenter online registry, 4,573 patients diagnosed as AMI in Korea from January to December 2006 were included. The highest incidence of AMI was between 8 a.m. and noon. The number of cases was highest in the winter and lowest in the autumn (13.6 vs 11.4 patients per day, P<0.001). Patients with symptom onset during working hours had a shorter time to first medical contact (203±288 min) compared with out-of-hours onset (230±288 min, P=0.003). In patients who underwent primary angioplasty, out-of hours symptom onset was associated with a greater time delay in both the patient's and the medical facility's response (door-to-balloon time out-of hours vs working hours: 101±54 min vs 84±44 min, P<0.001). In patients with ST-segment elevation myocardial infarction, symptoms to first medical contact showed a significant relationship to in-hospital mortality (for every 10 min of symptoms to first medical contact, odds ratio 1.006, 95% confidence interval 1.001-1.012, P=0.018) Conclusions: Circadian and periodic variation in AMI exists in Korean patients, which resulted in different patient behavior, hospital management and outcomes. (Circ J 2010; 74: 970 - 976)
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