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Cited 9 time in webofscience Cited 12 time in scopus
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Dynamic changes in liver stiffness during the course of acute hepatitis A

Authors
Seo, Yeon SeokLee, Kwang GyunJung, Eun SukAn, HyongginPark, SanghoonKeum, BoraYim, Hyung JoonJeen, Yoon TaeChun, Hoon JaiKim, Chang DuckRyu, Ho SangUm, Soon Ho
Issue Date
Apr-2010
Publisher
Taylor & Francis
Keywords
Elastography; international normalized ratio; necroinflammation; overestimation; stiffness
Citation
Scandinavian Journal of Gastroenterology, v.45, no.4, pp 449 - 456
Pages
8
Indexed
SCI
SCIE
SCOPUS
Journal Title
Scandinavian Journal of Gastroenterology
Volume
45
Number
4
Start Page
449
End Page
456
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15024
DOI
10.3109/00365520903536515
ISSN
0036-5521
1502-7708
Abstract
Objective. Several recent studies have suggested that hepatic necroinflammation can alter the results of liver stiffness measurements (LSMs) obtained using the FibroScan device. However, the precise relationship between acute hepatic inflammation and LSMs remains unclear. The aim of this study was therefore to evaluate the dynamic changes in LSMs during the course of acute hepatic inflammation. Material and methods. Thirty-one patients with acute hepatitis A (AHA) were enrolled in this study (mean +/- SD age 29 +/- 7 years; 32.3% male). Only AHA patients who visited our hospital before their alanine aminotransferase (ALT) levels peaked were included. The day when AHA-associated symptoms began was considered as Day 0. Serum levels of ALT and bilirubin (BIL), and the international normalized ratio (rNR) were measured every 2 days, as were LSMs, until the peak levels of all parameters were identified. Subsequently, these parameters were measured every 1-2 weeks until they had normalized. Results. Peak serum levels of ALT and BIL, the INR, and LSMs were 3723 +/- 1513 IU/1, 5.8 +/- 2.4 mg/dl, 1.3 +/- 0.3, and 11.9 +/- 5.7 kPa, respectively. The time taken for LSMs to peak from Day 0 (8 +/- 2 days) differed significantly from that for ALT (5 +/- 1 days), BIL (10 +/- 4 days), and INR (5 +/- 1 days). LSMs had normalized (<= 5.5 kPa) in all patients at 34 +/- 17 days after Day 0. ALT level and the INR were significantly associated with peak LSMs and BIL level and the INR with the time taken for normalization of LSMs. Conclusions. LSMs changed dynamically during the course of AHA. The pattern of change appears to be related to the severity of hepatic necroinflammation.
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