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Cited 5 time in webofscience Cited 6 time in scopus
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Low Levels of Plasma Agmatine in the Metabolic Syndrome

Authors
Jo, InhoHan, ChangsuJo, Sangmee AhnSeo, Ji AhPark, Moon HoKim, Nan Hee
Issue Date
Feb-2010
Publisher
MARY ANN LIEBERT, INC
Citation
METABOLIC SYNDROME AND RELATED DISORDERS, v.8, no.1, pp 21 - 24
Pages
4
Indexed
SCIE
SCOPUS
Journal Title
METABOLIC SYNDROME AND RELATED DISORDERS
Volume
8
Number
1
Start Page
21
End Page
24
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15161
DOI
10.1089/met.2009.0032
ISSN
1540-4196
1557-8518
Abstract
Background: The biophysiology of the amino acid L-arginine has been a field of active research. Agmatine, which is a metabolite of L-arginine, is known to participate in many biophysical reactions, including those in the cardiovascular system. We sought to investigate plasma agmatine levels in human subjects as a potential biomarker for the metabolic syndrome. Methods: Agmatine concentration was measured in plasma from 322 elderly participants in the Ansan Geriatric study. The metabolic syndrome was defined according to an Asian modified version of criteria established in the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. We observed that the metabolic syndrome was associated with low levels of plasma agmatine concentration. Results: The mean plasma agmatine level in the metabolic syndrome group was lower than that in the non-metabolic syndrome group (79.42 ng/mL vs. 82.44 ng/mL, P = 0.024). Agmatine remained significant within the regression model after adjustment for different covariates (adjusted odds ratio, 0.962; 95% confidence interval, 0.933-0.993). Conclusions: We concluded that plasma agmatine levels were lower in subjects with the metabolic syndrome than in those without the metabolic syndrome.
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2. Clinical Science > Department of Neurology > 1. Journal Articles
2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles
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Han, Changsu
Ansan Hospital (Department of Psychiatry, Ansan Hospital)
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