Detailed Information

Cited 18 time in webofscience Cited 25 time in scopus
Metadata Downloads

Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients

Authors
Lee, Hwa-YoungKim, Yong-Ku
Issue Date
Jan-2010
Publisher
ELSEVIER IRELAND LTD
Keywords
Manic patients; Catechol-O-methyltransferase (COMT); Polymorphism; Therapeutic response
Citation
PSYCHIATRY RESEARCH, v.175, no.1-2, pp.63 - 66
Indexed
SCIE
SSCI
AHCI
SCOPUS
Journal Title
PSYCHIATRY RESEARCH
Volume
175
Number
1-2
Start Page
63
End Page
66
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15220
DOI
10.1016/j.psychres.2008.09.011
ISSN
0165-1781
Abstract
Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response. This study comprised 144 unrelated manic patients who met strict DSM-IV criteria for bipolar I disorder and 157 healthy unrelated controls. All subjects were of Korean ethnicity. To evaluate the clinical symptoms, we used the Young Mania Rating Scale at baseline and 6 weeks after treatment. No statistically significant difference in genotype distribution was found between manic patients and normal controls. There was also no significant difference in symptornatology among the genotypes in manic patients. In therapeutic response, however, patients with the Met/Met genotype were significantly more frequent in the non-responder than in the responder group. Our results suggest that the COMT gene polymorphism in the therapeutic response to mood stabilizers in manic patients. Further studies with a larger number of subjects and well-controlled design will be required to better understand the role of the COMT gene polymorphism on the therapeutic response to mood stabilizer in manic patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Psychiatry > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Yong Ku photo

Kim, Yong Ku
안산병원 (Department of Psychiatry, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE