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Cited 20 time in webofscience Cited 23 time in scopus
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Usefulness of Non-invasive Markers for Predicting Significant Fibrosis in Patients with Chronic Liver Disease

Authors
Lee, Han HyoSeo, Yeon SeokUm, Soon HoWon, Nam HeeYoo, HannaJung, Eun SukKwon, Yong DaePark, SanghoonKeum, BoraKim, Yong SikYim, Hyung JoonJeen, Yoon TaeChun, Hoon JaiKim, Chang DuckRyu, Ho Sang
Issue Date
Jan-2010
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Liver Cirrhosis; Biological Markers; Chronic Liver Disease
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.1, pp 67 - 74
Pages
8
Indexed
SCI
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
25
Number
1
Start Page
67
End Page
74
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15241
DOI
10.3346/jkms.2010.25.1.67
ISSN
1011-8934
1598-6357
Abstract
The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined as >= F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, alpha 2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, alpha 2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease.
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
1. Basic Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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