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Cited 12 time in webofscience Cited 15 time in scopus
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Impact of timing to source control in patients with septic shock: A prospective multi-center observational study

Authors
Kim, HongjungChung, Sung PhilChoi, Sung-HyukKang, Gu HyunShin, Tae GunKim, KyuseokPark, Yoo SeokHan, Kap SuChoi, Han SungSuh, Gil JoonKim, Won YoungLim, Tae HoKo, Byuk Sung
Issue Date
Oct-2019
Publisher
W. B. Saunders Co., Ltd.
Keywords
Septic shock; Infection control; Emergency service; Hospital
Citation
Journal of Critical Care, v.53, pp 176 - 182
Pages
7
Indexed
SCI
SCIE
SCOPUS
Journal Title
Journal of Critical Care
Volume
53
Start Page
176
End Page
182
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1542
DOI
10.1016/j.jcrc.2019.06.012
ISSN
0883-9441
1557-8615
Abstract
Purpose Current guidelines recommend that rapid source control should be adopted in patients not >6–12 h after sepsis is diagnosed. However, evidence level of this guideline is not specified, and there is no previous study on patients with septic shock visiting the emergency department (ED). Therefore, we aimed to assess the impact of rapid source control in patients with septic shock visiting the ED. Materials and methods In a prospective, observational, multicenter, registry-based study in 11 EDs, Cox proportional hazards model was used to assess the independent effect of source control and time to source control on 28-day mortality. Results Cox proportional hazard models revealed that 28-day mortality was significantly lower in patients who underwent source control (HR 0.538 (0.389–0.744), p < .001). However, no significant association between the performance of source control after 6 h or 12 h from enrollment and 28-day mortality was noted. Conclusions Patients with septic shock visiting the ED who underwent source control showed better outcomes than those who did not. We failed to demonstrate the performance of rapid source control reduced the 28-day mortality in septic shock patients. Further studies are required to determine the impact of rapid source control in sepsis and septic shock.
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Han, Kap Su
Anam Hospital (Department of Emergency Medicine, Anam Hospital)
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