Clinical Features and Prognosis of Spontaneous Bacterial Peritonitis in Korean Patients with Liver Cirrhosis: A Multicenter Retrospective Studyopen access
- Heo, Jeong; Seo, Yeon Seok; Yim, Hyung Joon; Hahn, Taeho; Park, Sang Hoon; Ahn, Sang Hoon; Park, Jun Yong; Park, Ji Young; Kim, Moon Young; Park, Sung Keun; Cho, Mong; Um, Soon Ho; Han, Kwang Hyub; Kim, Hong Soo; Baik, Soon Koo; Kim, Byung Ik; Cho, Se Hyun
- Issue Date
- EDITORIAL OFFICE GUT & LIVER
- Liver cirrhosis; Peritonitis; Prognosis; Resistance
- GUT AND LIVER, v.3, no.3, pp.197 - 204
- Journal Title
- GUT AND LIVER
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- Background/Aims: Although early recognition and treatment with effective antibiotics have lead to improvements in the prognosis of patients with spontaneous bacterial peritonitis (SBP), it remains to be a serious complication in cirrhotic patients. This study was designed to evaluate the clinical manifestations and prognosis of patients with liver cirrhosis and SBP in Korea. Methods: This was a multicenter retrospective study examining 157 episodes of SBP in 145 patients with cirrhosis. SBP was diagnosed based on a polymorphonuclear cell count in ascitic fluid of >250 cells/mm(3) in the absence of data compatible with secondary peritonitis. Results: The mean age of the cohort was 56 years, and 121 (77%) of the 157 episodes of SBP occurred in men. Microorganisms were isolated in 66 episodes (42%): Gram-negative bacteria in 54 (81.8%), Gram-positive in 11 (16.7%), and Candida in 1. Isolated Gram-negative organisms were resistant to third-gene ration cephalosporin in 6 cases (17%), to ciprofloxacin in 11 (20.8%), and to penicillin in 33 (62.3%). The treatment failure and in-hospital mortality rates were 12.1% and 21%, respectively. A high Model of End-Stage Liver Disease (MELD) score, SBP caused by extended-spectrum beta-lactamase-producing organisms, and hepatocellular carcinoma were independent prognostic factors of high in-hospital mortality. Conclusions: SBP remains to be a serious complication with high in-hospital mortality, especially in patients with a high MELD score. (Gut and Liver 2009;3:197-204)
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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