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Cited 40 time in webofscience Cited 39 time in scopus
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Clinical Features and Prognosis of Spontaneous Bacterial Peritonitis in Korean Patients with Liver Cirrhosis: A Multicenter Retrospective Studyopen access

Authors
Heo, JeongSeo, Yeon SeokYim, Hyung JoonHahn, TaehoPark, Sang HoonAhn, Sang HoonPark, Jun YongPark, Ji YoungKim, Moon YoungPark, Sung KeunCho, MongUm, Soon HoHan, Kwang HyubKim, Hong SooBaik, Soon KooKim, Byung IkCho, Se Hyun
Issue Date
Sep-2009
Publisher
EDITORIAL OFFICE GUT & LIVER
Keywords
Liver cirrhosis; Peritonitis; Prognosis; Resistance
Citation
GUT AND LIVER, v.3, no.3, pp.197 - 204
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
GUT AND LIVER
Volume
3
Number
3
Start Page
197
End Page
204
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15825
DOI
10.5009/gnl.2009.3.3.197
ISSN
1976-2283
Abstract
Background/Aims: Although early recognition and treatment with effective antibiotics have lead to improvements in the prognosis of patients with spontaneous bacterial peritonitis (SBP), it remains to be a serious complication in cirrhotic patients. This study was designed to evaluate the clinical manifestations and prognosis of patients with liver cirrhosis and SBP in Korea. Methods: This was a multicenter retrospective study examining 157 episodes of SBP in 145 patients with cirrhosis. SBP was diagnosed based on a polymorphonuclear cell count in ascitic fluid of >250 cells/mm(3) in the absence of data compatible with secondary peritonitis. Results: The mean age of the cohort was 56 years, and 121 (77%) of the 157 episodes of SBP occurred in men. Microorganisms were isolated in 66 episodes (42%): Gram-negative bacteria in 54 (81.8%), Gram-positive in 11 (16.7%), and Candida in 1. Isolated Gram-negative organisms were resistant to third-gene ration cephalosporin in 6 cases (17%), to ciprofloxacin in 11 (20.8%), and to penicillin in 33 (62.3%). The treatment failure and in-hospital mortality rates were 12.1% and 21%, respectively. A high Model of End-Stage Liver Disease (MELD) score, SBP caused by extended-spectrum beta-lactamase-producing organisms, and hepatocellular carcinoma were independent prognostic factors of high in-hospital mortality. Conclusions: SBP remains to be a serious complication with high in-hospital mortality, especially in patients with a high MELD score. (Gut and Liver 2009;3:197-204)
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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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