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Cited 7 time in webofscience Cited 8 time in scopus
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Caffeic acid phenethyl ester accumulates beta-catenin through GSK-3 beta and participates in proliferation through mTOR in C2C12 cells

Authors
Lee, Eun SooLee, Jung-OkLee, Soo KyungKim, Ji HaeJung, Jin HeeKeum, BoraPark, Sun-HwaKim, Hyeon Soo
Issue Date
22-May-2009
Publisher
Elsevier BV
Keywords
Akt; beta-catenin; CAPE; GSK-3 beta; mTOR
Citation
Life Sciences, v.84, no.21-22, pp.755 - 759
Indexed
SCOPUS
Journal Title
Life Sciences
Volume
84
Number
21-22
Start Page
755
End Page
759
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16005
DOI
10.1016/j.lfs.2009.03.004
ISSN
0024-3205
Abstract
Aim: The aim of this study is to characterize the roles of caffeic acid phenethyl ester (CAPE) in the skeletal muscle cells. Main methods: We performed immunoblotting assay using various phosphorylation specific antibodies. Key findings: We found that CAPE induces rapid and transient phosphorylation of glycogen synthase kinase (GSK)-3 beta in a phosphoinositide 3-kinase (PI3K)-dependent manner. CAPE also decreases phosphorylation of beta-catenin, ultimately leading to beta-catenin accumulation. In addition, we demonstrated that CAPE activated the mammalian target of rapamycin (mTOR)-p70 S6 ribosomal kinase (S6K) and also stimulated extracellular signal-regulated kinase (ERK). The inhibition of mTOR blocked CAPE-induced ERK phosphorylation. Significance: Our results suggest that CAPE may act through beta-catenin accumulation via stimulation of GSK-3 beta and may also participate in cellular proliferation through the mTOR-ERK pathway. (C) 2009 Elsevier Inc. All rights reserved.
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