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Cited 12 time in webofscience Cited 12 time in scopus
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G-protein beta 3 Subunit Gene 82SC/T Polymorphism Is Not Associated with Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients

Authors
Park, Young-MinChung, Young-ChoLee, Seung-HwanLee, Kang-JoonKim, HyunChoi, Jung-EunKang, Seung-GulLee, Min-SooKim, LeenLee, Heon-Jeong
Issue Date
Mar-2009
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Olanzapine; Weight; Polymorphism; Schizophrenia
Citation
PSYCHIATRY INVESTIGATION, v.6, no.1, pp 39 - 43
Pages
5
Indexed
SCIE
SCOPUS
KCICANDI
Journal Title
PSYCHIATRY INVESTIGATION
Volume
6
Number
1
Start Page
39
End Page
43
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16192
DOI
10.4306/pi.2009.6.1.39
ISSN
1738-3684
1976-3026
Abstract
Objective Weight gain is a possible adverse effect of the use of antipsychotics, and is an important factor for long-term health and treatment compliance. Olanzapine is an atypical antipsychotic known to cause considerable weight gain. A relationship between weight gain and the G protein beta 3 subunit gene (GNB3) 825C/T polymorphism has been reported. We therefore examined this possible association in a Korean schizophrenic patient group receiving olanzapine treatment. Methods Weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the 825C/T polymorphism was performed using a PCR-based method. Results We found that long-term treatment with olanzapine resulted in mean gains in weight and body mass index (BMI) of 5.2 kg and 1.93 kg/m(2), respectively. There was a no significant difference in the mean body weight it change from baseline to the endpoint after olanzapine treatment between the genotype groups (p=0.796). There were also no significant differences in genotype or allele frequencies between the severe weight-gain (more than 10%) and minimal weight-gain (less than 10%) groups (chi(2)=0.037, p=0.98; chi(2)=0.020, p=0.89). Conclusion The Finding from this study thus does not support a relationship between the GNB3 825C/T polymorphism and weight gain in Korean schizophrenic patients receiving olanzapine treatment.
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Lee, Heon Jeong
Anam Hospital (Department of Psychiatry, Anam Hospital)
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