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Cited 10 time in webofscience Cited 9 time in scopus
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Unmet Psychosocial Needs of Patients with Newly Diagnosed Ulcerative Colitis: Results from the Nationwide Prospective Cohort Study in Korea

Authors
Moon, Jung RockLee, Chang KyunHong, Sung NohIm, Jong PilYe, Byong DukCha, Jae MyungJung, Sung AeLee, Kang MoonPark, Dong IlJeen, Yoon TaePark, Young SookCheon, Jae HeeKim, Hye SungSeo, Bo JeongKim, Young DoeKim, Hyo Jong
Issue Date
Jul-2020
Publisher
거트앤리버 발행위원회
Keywords
Colitis; ulcerative; Patient reported outcome measures; Quality of life; Anxiety; Depression
Citation
Gut and Liver, v.14, no.4, pp.459 - 467
Indexed
SCIE
SCOPUS
KCI
Journal Title
Gut and Liver
Volume
14
Number
4
Start Page
459
End Page
467
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1647
DOI
10.5009/gnl19107
ISSN
1976-2283
Abstract
Background/Aims: Limited data are available regarding psychosocial distress at the time of diagnosis of ulcerative colitis (UC). We investigated the psychosocial burden and factors related to poor health-related quality of life (HRQL) among patients newly diagnosed with moderate-to-severe UC who were affiliated with the nationwide prospective cohort study. Methods: Within the first 4 weeks of UC diagnosis, all patients were assessed using the Hospital Anxiety and Depression Scale (HADS), Work Productivity and Activity Impairment questionnaire, Inflammatory Bowel Disease Questionnaire (IBDQ), and 12-Item Short Form (SF-12) health survey. A multiple linear regression model was used to identify factors associated with HRQL. Results: Between August 2014 and February 2017, 355 patients completed questionnaires. Significant mood disorders requiring psychological interventions, defined by a HADS score ≥11, were identified in 16.7% (anxiety) and 20.6% (depression) of patients. Patients with severe disease were more likely to have presenteeism, loss of work productivity, and activity loss than those with moderate disease (all p<0.05). Significant mood disorders had the strongest negative relationship with total IBDQ score, which indicates disease-specific HRQL (β coefficient: ?22.1 for depression and ?40.0 for anxiety, p<0.001). The scores of all SF-12 dimensions, which indicate general HRQL, were remarkably decreased in the study population compared indirectly with previously reported scores in the general population. The Mayo score, C-reactive protein level, and white blood cell count showed significant negative associations with the IBDQ score (p<0.05). Conclusions: Psychosocial screening and timely interventions should be incorporated into the initial care of patients newly diagnosed with UC.
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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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