Unmet Psychosocial Needs of Patients with Newly Diagnosed Ulcerative Colitis: Results from the Nationwide Prospective Cohort Study in Korea
- Moon, Jung Rock; Lee, Chang Kyun; Hong, Sung Noh; Im, Jong Pil; Ye, Byong Duk; Cha, Jae Myung; Jung, Sung Ae; Lee, Kang Moon; Park, Dong Il; Jeen, Yoon Tae; Park, Young Sook; Cheon, Jae Hee; Kim, Hye Sung; Seo, Bo Jeong; Kim, Young Doe; Kim, Hyo Jong
- Issue Date
- 거트앤리버 발행위원회
- Colitis; ulcerative; Patient reported outcome measures; Quality of life; Anxiety; Depression
- Gut and Liver, v.14, no.4, pp.459 - 467
- Journal Title
- Gut and Liver
- Start Page
- End Page
- Background/Aims: Limited data are available regarding psychosocial distress at the time of diagnosis of ulcerative colitis (UC). We investigated the psychosocial burden and factors related to poor health-related quality of life (HRQL) among patients newly diagnosed with moderate-to-severe UC who were affiliated with the nationwide prospective cohort study. Methods: Within the first 4 weeks of UC diagnosis, all patients were assessed using the Hospital Anxiety and Depression Scale (HADS), Work Productivity and Activity Impairment questionnaire, Inflammatory Bowel Disease Questionnaire (IBDQ), and 12-Item Short Form (SF-12) health survey. A multiple linear regression model was used to identify factors associated with HRQL. Results: Between August 2014 and February 2017, 355 patients completed questionnaires. Significant mood disorders requiring psychological interventions, defined by a HADS score ≥11, were identified in 16.7% (anxiety) and 20.6% (depression) of patients. Patients with severe disease were more likely to have presenteeism, loss of work productivity, and activity loss than those with moderate disease (all p<0.05). Significant mood disorders had the strongest negative relationship with total IBDQ score, which indicates disease-specific HRQL (β coefficient: ?22.1 for depression and ?40.0 for anxiety, p<0.001). The scores of all SF-12 dimensions, which indicate general HRQL, were remarkably decreased in the study population compared indirectly with previously reported scores in the general population. The Mayo score, C-reactive protein level, and white blood cell count showed significant negative associations with the IBDQ score (p<0.05). Conclusions: Psychosocial screening and timely interventions should be incorporated into the initial care of patients newly diagnosed with UC.
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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