Significance of anti-HCV signal-to-cutoff ratio in predicting hepatitis C viremia
DC Field | Value | Language |
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dc.contributor.author | Seo Y.S. | - |
dc.contributor.author | Jung E.S. | - |
dc.contributor.author | Kim J.H. | - |
dc.contributor.author | Jung Y.K. | - |
dc.contributor.author | Kim J.H. | - |
dc.contributor.author | An H. | - |
dc.contributor.author | Yim H.J. | - |
dc.contributor.author | Yeon J.E. | - |
dc.contributor.author | Byun K.S. | - |
dc.contributor.author | Kim C.D. | - |
dc.contributor.author | Ryu H.S. | - |
dc.contributor.author | Um S.H. | - |
dc.date.available | 2020-11-03T09:44:58Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16523 | - |
dc.description.abstract | Background/Aims: Hepatitis C virus (HCV) RNA testing can be performed using qualitative or quantitative assays, and it is still unclear which is more useful as a primary test in patients positive for anti-HCV. The present study evaluated the usefulness of anti-HCV signal-to-cutoff ratio (S/CO ratio) for predicting HCV RNA results. Methods: Patients on whom a qualitative HCV RNA test was performed due to a positive anti-HCV enzyme immunoassay were enrolled. Patients were divided into viremia and no-viremia groups according to HCV RNA results. Receiver-operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of anti-HCV S/CO for a diagnosis of viremia. Results: In total, 487 patients were enrolled. HCV RNA was positive in 301 subjects (61.8%). Age, serum ALT level, and anti-HCV S/CO ratio were significantly different between the viremia and no-viremia groups. By ROC curve analysis, anti-HCV S/CO ratio (area, 0.989; 95% confidence interval, 0.981 to 0.998) accurately predicted the presence of viremia, with a cutoff value of 10.9 (sensitivity, 94.4%; specificity, 97.3%). Conclusions: Anti-HCV S/CO ratio was found to be highly accurate at predicting HCV viremia. The anti-HCV S/CO ratio can be used to determine whether a quantitative or qualitative HCV RNA test should be used to confirm HCV viremia in patients with a positive anti-HCV by the following criteria: if the anti-HCV S/CO ratio is <10.9, a qualitative HCV RNA test can be used, and if the anti-HCV S/CO ratio is ≥10.9 a quantitative HCV RNA test can be performed. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Significance of anti-HCV signal-to-cutoff ratio in predicting hepatitis C viremia | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3904/kjim.2009.24.4.302 | - |
dc.identifier.scopusid | 2-s2.0-72049128038 | - |
dc.identifier.bibliographicCitation | Korean Journal of Internal Medicine, v.24, no.4, pp 302 - 308 | - |
dc.citation.title | Korean Journal of Internal Medicine | - |
dc.citation.volume | 24 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 302 | - |
dc.citation.endPage | 308 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001393785 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | alanine aminotransferase | - |
dc.subject.keywordPlus | virus RNA | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | alanine aminotransferase blood level | - |
dc.subject.keywordPlus | antibody titer | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diagnostic accuracy | - |
dc.subject.keywordPlus | enzyme immunoassay | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | Hepatitis C virus | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | immunoblotting | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | parameter | - |
dc.subject.keywordPlus | prediction | - |
dc.subject.keywordPlus | qualitative analysis | - |
dc.subject.keywordPlus | receiver operating characteristic | - |
dc.subject.keywordPlus | RNA analysis | - |
dc.subject.keywordPlus | signal to cutoff ratio | - |
dc.subject.keywordPlus | viremia | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Aged | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Hepatitis C | - |
dc.subject.keywordPlus | Hepatitis C Antibodies | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Immunoenzyme Techniques | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Middle Aged | - |
dc.subject.keywordPlus | RNA, Viral | - |
dc.subject.keywordPlus | Viremia | - |
dc.subject.keywordAuthor | Antibody titer | - |
dc.subject.keywordAuthor | Enzyme immunoassay | - |
dc.subject.keywordAuthor | Hepatitis C virus | - |
dc.subject.keywordAuthor | Viremia | - |
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