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Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway
- Issue Date
- 29-Nov-2008
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- ACC; AMPK; Calcium; Oxytocin; CaMKK
- Citation
- REGULATORY PEPTIDES, v.151, no.1-3, pp 71 - 74
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- REGULATORY PEPTIDES
- Volume
- 151
- Number
- 1-3
- Start Page
- 71
- End Page
- 74
- ISSN
- 0167-0115
1873-1686
- Abstract
- Oxytocin is a mammalian hormone that is released mainly after distension of the uterine cervix. In this study, we report that oxytocin stimulates intracellular release of calcium, and also activates AMPK (AMP-activated protein kinase) in C2C12 myoblast cells in a time/dose-dependent manner. Oxytocin receptor mRNA was detected in C2C12 cells. In addition, oxytocin stimulated glucose uptake and, moreover, inhibition of either CaMKK (Ca2+/calmodulin-dependent protein kinase kinase) or AMPK blocked oxytocin-mediated AMPK activation and glucose uptake. Taken together, our findings suggest that oxytocin may serve a peripheral metabolic function in skeletal muscle cells through the calcium-CaMKK-AMPK pathway. (C) 2008 Elsevier B.V. All rights reserved.
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Collections - 1. Basic Science > Department of Anatomy > 1. Journal Articles
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Related Researcher
- Park, Sun Hwa
- College of Medicine (Department of Anatomy)