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Cited 12 time in webofscience Cited 13 time in scopus
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Evaluation of the prognostic powers of various tumor status grading scales in patients with hepatocellular carcinoma

Authors
Seo, Yeon SeokKim, Young JinUm, Soon HoYoo, HannaLee, Jae WonKim, Yong SikJeen, Yoon TaeChun, Hoon JaiKim, Chang DuckRyu, Ho Sang
Issue Date
Aug-2008
Publisher
WILEY
Keywords
hepatocellular carcinoma; prognostic power; staging system
Citation
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.23, no.8, pp.1267 - 1275
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume
23
Number
8
Start Page
1267
End Page
1275
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16861
DOI
10.1111/j.1440-1746.2008.05480.x
ISSN
0815-9319
Abstract
Backgrounds and Aim: Several tumor status grading scales are available for patients with hepatocellular carcinoma (HCC), which include several tumor-node-metastasis (TNM) systems and clinical staging systems, such as Cancer of the Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC). This study was performed to analyze the prognostic powers of these tumor status grading systems in HCC. Methods: A retrospective cohort of 499 consecutive patients with HCC was included. The tumor statuses of all patients were classified according to several TNM systems (sixth version of the American Joint Committee on Cancer, fourth version of the Liver Cancer Study Group of Japan [LCSGJ], and the United Network for Organ Sharing UNOS system) and according to the tumor status grading scales of the BCLC (TBCLC) and CLIP (TCLIP) systems. Prognostic powers were quantified using a linear trend chi(2)-test, c-index, and the likelihood ratio (LHR) chi(2)-test, and correlated using Cox's regression model adjusted using the Akaike information criterion (AIC). Results: Of the TNM systems, the fourth LCSGJ system had the highest prognostic power (LHR chi(2) = 7.20, AIC = 4803.02). However, when TBCLC and TCLIP were included in the analysis, TCLIP showed the best predictive power (LHR chi(2) = 29.52, AIC = 4799.82). Conclusion: TCLIP had best predictive power in HCC patients of the various tumor staging systems examined. To improve prognostic power, factors other than tumor burden, such as tumor behavior, should be included in the tumor status grading system for HCC.
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5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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