Detailed Information

Cited 6 time in webofscience Cited 6 time in scopus
Metadata Downloads

Rapid re-emergence of YMDD mutation of hepatitis B virus with hepatic decompensation after aim lamivudine retreatment

Authors
Kwon, So YoungChoe, Won HyeokLee, Chang HongYeon, Jong EunByun, Kwan Soo
Issue Date
Jul-2008
Publisher
Baishideng Publishing Group
Keywords
hepatitis B; lamivudine; adefovir dipivoxil; mutations
Citation
World Journal of Gastroenterology, v.14, no.27, pp 4416 - 4419
Pages
4
Indexed
SCOPUS
Journal Title
World Journal of Gastroenterology
Volume
14
Number
27
Start Page
4416
End Page
4419
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16881
DOI
10.3748/wjg.14.4416
ISSN
1007-9327
2219-2840
Abstract
Lamivudine has a high rate of antiviral resistance. Sequential treatment of anti-hepatitis B virus (HBV) Is commonly used for lamivudine resistance. We report 4 cases of patients with rapid redetection of HBV mutants during the lamivudine retreatment. The four patients received lamivudine as an initial treatment of HBV and adefovir and lamivudine as a rescue therapy consecutively. HBV-DNA level, YMDD mutations and adefovir -resistant mutations (RFMP) were tested every 3 mo during the sequential treatment. All the patients showed YMDD mutations during the initial lamivudine therapy. After adefovir therapy for lamivudine resistance, they showed viral breakthrough. Adefovir was switched to lamivudine, however, it did not induce viral suppression at all, rather increased HBV-DNA with rapid reemergence of the YMDD mutations. All the patients had ALT flares, and hepatic decompensation occurred in two patients. After switching to adefovir combined with entecavir or lamivudine for a rescue therapy, the patients had reduction in HBV-DNA and ALT improvement. These cases demonstrated that lamivudine retreatment of patients with preexposed lamivudine resistance leads to rapid reemergence of YMDD mutation with significant viral rebounds and subsequent hepatic decompensation. Sequential administration of lamivudine in patients with a prior history of YMDD mutation should be abandoned. (c) 2008 The WJG Press. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yeon, Jong Eun photo

Yeon, Jong Eun
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE