Korean Red Ginseng Extract Increases Apoptosis by Activation of the Noxa Pathway in Colorectal Cancer
- Authors
- Jeong, Yoon A.; Kim, Bo Ram; Kim, Dae Young; Jeong, So yeon; Na, Yoo Jin; Kim, Jung Lim; Yun, Hye Kyeong; Kim, Bu Gyeom; Park, Seong Hye; Jo, Min Jee; Lee, Sun Il; Han, Byung-Cheol; Lee, Dae Hee; Oh, Sang Cheul
- Issue Date
- Sep-2019
- Publisher
- MDPI
- Keywords
- endoplasmic reticulum stress; korean red ginseng; Noxa; reactive oxygen species
- Citation
- NUTRIENTS, v.11, no.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRIENTS
- Volume
- 11
- Number
- 9
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1698
- DOI
- 10.3390/nu11092026
- ISSN
- 2072-6643
2072-6643
- Abstract
- Background: Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). In our study, we examined whether KRG induces apoptosis in CRC cells. Methods: In the cell viability assay, the concentration of the appropriate KRG extracts was fixed at 2.5 mg/mL in numerous CRC cells. This fixed concentration was in other experiments, and it was confirmed that the KRG extracts induce apoptosis in CRC cells. Results: We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells. Conclusion: Our results show that KRG can be used as a possible anticancer drug for patients with CRC
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- Appears in
Collections - 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
- 3. Graduate School > Graduate School > 1. Journal Articles
- 2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
- 4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles
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