Combination therapy of thymosin alpha-1 and lamivudine for HBeAg positive chronic hepatitis B: A prospective randomized, comparative pilot study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyun Woong | - |
dc.contributor.author | Lee, Joung I. I. | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Ahn, Sang Hoon | - |
dc.contributor.author | Chang, Hye Young | - |
dc.contributor.author | Park, Yong Kwang | - |
dc.contributor.author | Hong, Sun Pyo | - |
dc.contributor.author | Moon, Young Myoung | - |
dc.contributor.author | Han, Kwang-Hyub | - |
dc.date.available | 2020-11-03T10:45:29Z | - |
dc.date.issued | 2008-05 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.issn | 1440-1746 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17016 | - |
dc.description.abstract | Background and Aim: Monotherapy of lamivudine, interferon-alpha (IFN-alpha), and thymosin alpha-1 (T alpha 1) is unlikely to be sufficient for the eradication of a chronic hepatitis B virus ( HBV) infection. The aim of our study is to elucidate whether the combination of Ta1 and lamivudine is superior to lamivudine monotherapy in hepatitis B e antigen ( HBeAg) positive naive patients with chronic hepatitis B. Methods: Sixty-seven patients were assigned to two different groups in a randomized manner. The combination group (n = 34) received Ta1 (1.6 mg subcutaneously, twice a week) and lamivudine ( 100 mg orally, daily) for 24 weeks, followed by continuous lamivudine therapy. The monotherapy group ( n = 33) received lamivudine monotherapy continuously. Results: The incidence of HBeAg seroconversion at 24 weeks was 26.5% ( 9/ 34) in the combination group and 6.1% (2/33) in the monotherapy group ( P = 0.024). However, there was no statistically significant difference between 26.5% ( 9/ 34) in the combination group and 12.1% (4/33) in the monotherapy group at 52 weeks ( P = 0.138). The emergence of viral breakthrough gradually increased to 35.3% (12/34) in the combination group, and to 21.2% (7/33) in the monotherapy group at 52 weeks ( P = 0.201). Conclusions: The combination treatment of Ta1 and lamivudine did not have an obvious benefit of virological and biochemical response as compared to the lamivudine monotherapy during the combination period. In addition, after the cessation of Ta1 treatment, the combination therapy did not prevent the occurrence of viral and biochemical breakthroughs. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Combination therapy of thymosin alpha-1 and lamivudine for HBeAg positive chronic hepatitis B: A prospective randomized, comparative pilot study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1440-1746.2008.05387.x | - |
dc.identifier.scopusid | 2-s2.0-42049106464 | - |
dc.identifier.wosid | 000254809300010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.23, no.5, pp 729 - 735 | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 729 | - |
dc.citation.endPage | 735 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | VIRUS-INFECTION | - |
dc.subject.keywordPlus | CLINICAL-TRIAL | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | ANTI-HBE | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | PHASE | - |
dc.subject.keywordPlus | GENOTYPES | - |
dc.subject.keywordAuthor | chronic hepatitis B | - |
dc.subject.keywordAuthor | lamivudine | - |
dc.subject.keywordAuthor | thymosin | - |
dc.subject.keywordAuthor | treatment | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.