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Cited 7 time in webofscience Cited 10 time in scopus
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An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females

Authors
Lee, Boung-ChulYang, Jae-WonLee, So-HeeKim, Seung-HyunJoe, Sook-HaengJung, In-KwaChoia, Ihn-GeunHam, Byung-Joo
Issue Date
1-Jan-2008
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
genes; monoamine oxidase-A; norepinephrine transporter; personality; polymorphism
Citation
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.32, no.1, pp.238 - 242
Indexed
SCIE
SCOPUS
Journal Title
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume
32
Number
1
Start Page
238
End Page
242
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17200
DOI
10.1016/j.pnpbp.2007.08.014
ISSN
0278-5846
Abstract
The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic system, to elucidate their relationship with personality. A total of 245 normal female Koreans (age 23.05 +/- 3.07 years, mean +/- SD) volunteered to take part in this study. They filled out a Korean version of the Temperament and Character Inventory (TCI) and were genotyped for the NET and MAOA-VNTR; the NET T-182C and MAOA-uVNTR polymorphisms were checked. We found significant main effect of NET genotype on novelty seeking (NS) score (F=5.43, p=0.021) and significant interaction between the NET and MAOA-uVNTR polymorphisms on NS score (F=11.06, p=0.001). However, there were no relationship between MAOA-uVNTR polymorphisms and NS score, and no association with other temperamental dimensions and these two polymorphisms. Our findings suggest that this functional polymorphism in the noradrenergic gene is associated with novelty seeking in Korean females. (c) 2007 Elsevier Inc. All rights reserved.
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Ham, Byung Joo
Anam Hospital (Department of Psychiatry, Anam Hospital)
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