Possible association between the-2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain
- Authors
- Kang, Seung-Gul; Lee, Heon-Jeong; Park, Young-Min; Choi, Jung-Eun; Han, Changsu; Kim, Yong-Ku; Kim, Seung-Hyun; Lee, Min-Soo; Joe, Sook-Haeng; Jung, In-Kwa; Kim, Leen
- Issue Date
- 1-Jan-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- leptin gene; olanzapine; polymorphism; schizophrenia; weight gain
- Citation
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.32, no.1, pp 160 - 163
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Volume
- 32
- Number
- 1
- Start Page
- 160
- End Page
- 163
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17201
- DOI
- 10.1016/j.pnpbp.2007.08.002
- ISSN
- 0278-5846
1878-4216
- Abstract
- Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a -2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the -2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment lasting for at least 3 months. The weight gain was significantly higher for patients with the AG genotype than for those with the AA genotype (p=0.029). Analysis of covariance also showed the difference of weight gain was still significant when adjusted for sex and treatment duration (p=0.046). This finding supports the presence of a relationship between the -2548A/G SNP of the leptin gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment. (c) 2007 Elsevier Inc. All rights reserved.
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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