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양극성 장애 환자에서 급성 조증기 및 관해기 사이의 인지기능 변화와 조증 증상과의 상관성Changes of Cognitive Function and the Relationship with Manic Symptoms between Acute Manic and Euthymic States in Patients with Bipolar Disorder

Other Titles
Changes of Cognitive Function and the Relationship with Manic Symptoms between Acute Manic and Euthymic States in Patients with Bipolar Disorder
Authors
허지원김용구
Issue Date
2008
Publisher
대한신경정신의학회
Keywords
Bipolar disorder·Manic·Remission·Cognition·Attention·Memory·Neuropsychology.; 양극성장애·조증·관해·인지기능·주의력·기억력·실행기능.
Citation
신경정신의학, v.47, no.4, pp 325 - 333
Pages
9
Indexed
KCI
Journal Title
신경정신의학
Volume
47
Number
4
Start Page
325
End Page
333
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17358
ISSN
1015-4817
Abstract
Objectives:The purpose of this study was to investigate 1) whether the change of manic symptoms in bipolar patients would be correlated with cognitive functions and 2) whether there would be significant changes in the cognitive function between acute manic and euthymic states. Methods:The thirty-five patients who were diagnosed as manic episode by DSM-IV and SCID-IV interview participated in this study. The memory function, executive function, and sustained attention were measured using Memory Assessment Scale (MAS), Wisconsin Card Sorting Test (WCST), and Vigilance (VIG) and Cognitrone (COG) in the Vienna Test System respectively. The psychopathology was measured using Young Mania Rating Scale (YMRS) and Brief Psychiatric Rating Scale (BPRS) by a trained psychologist. After 6 weeks of drug treatment, the cognitive tests and psychopathology were retested by the same psychologist. Results:The normal control group (N=76) and bipolar disorder patients group (N=35) showed different neurocognitive performance which were performed at baseline. After 6 weeks of medication, the YMRS and BPRS scores in the patient group decreased significantly. Although the psychiatric symptoms were attenuated, most of the neurocognitive functions including attention, psychomotor speed, memory (N=34), and frontal/executive function (N=35) were still impaired after treatment. Furthermore, the correlations between the variation of psychiatric symptoms and the differences in neurocognitive functions were statistically insignificant. Conclusion:This study provides an evidence for distinct neuropsychological dysfunctions in acute manic state in bipolar disorder patients. Besides, the impairments of neuropsychological functioning remain after medication and remission. These neuropsychological dysfunctions might be one of the trait markers of the disorder, and we suggest that the dysfunctions make the bipolar disorder patients with medication still experience difficult to adjust daily life. (J Korean Neuropsychiatr Assoc 2008; 47(4):325-333)
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