No association between dopamine D3 receptor gene Ser9Gly polymorphism and tardive dyskinesia in schizophrenia
- Authors
- Lee H.-J.; Kang S.-G.; Choi J.-E.; Park Y.-M.; Lim S.-W.; Kim L.
- Issue Date
- 2008
- Keywords
- Dopamine 3 receptor; Polymorphism; Tardive dyskinesia
- Citation
- Clinical Psychopharmacology and Neuroscience, v.6, no.2, pp 71 - 74
- Pages
- 4
- Indexed
- SCOPUS
KCICANDI
- Journal Title
- Clinical Psychopharmacology and Neuroscience
- Volume
- 6
- Number
- 2
- Start Page
- 71
- End Page
- 74
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17405
- ISSN
- 1738-1088
2093-4327
- Abstract
- Objective: Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic drug use. Ser9Gly polymorphism of the dopamine 3 receptor (DRD3) has been shown to affect dopamine binding affinity, and may contribute to the susceptibility of antipsychotic-induced TD. This study investigated the possible association between DRD3 gene variant and TD. Methods: We evaluated whether a DRD3 Ser9Gly polymorphism is associated with antipsychotic-induced TD in 209 Korean schizophrenia patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables. Results: There was no significant association between genotype and allele frequencies determined by the Ser9Gly polymorphism of DRD3 between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Ser9Gly polymorphism of DRD3 does not contribute significantly to the risk of TD. Copyright © 2008 Korean College of Neuropsychopharmacology.
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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