Detailed Information

Cited 0 time in webofscience Cited 212 time in scopus
Metadata Downloads

A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinomaopen access

Park J.-W.Ji H.K.Seok K.K.Keon W.K.Kyung W.P.Choi J.-I.Woo J.L.Kim C.-M.Byung H.N.
Issue Date
Acetate; FDG; Hepatocellular carcinoma; Hepatology; Oncology; PET/CT; Sensitivity
Journal of Nuclear Medicine, v.49, no.12, pp.1912 - 1921
Journal Title
Journal of Nuclear Medicine
Start Page
End Page
Because 18F-FDG PET has insufficient sensitivity for the detection of hepatocellular carcinoma (HCC), 11C-acetate PET has been proposed as another technique for this use. We prospectively evaluated the value of PET/CT using these 2 tracers for the detection of primary and metastatic HCC. Methods: One hundred twelve patients (99 with HCC, 13 with cholangiocellular carcinoma) underwent biopsy and 18F-FDG and 11C-acetate PET/CT. Results: The overall sensitivities of 18F-FDG, 11C-acetate, and dual-tracer PET/CT in the detection of 110 lesions in 90 patients with primary HCC were 60.9%, 75.4%, and 82.7%, respectively. Elevated serum α-fetoprotein levels, an advanced tumor stage, portal vein tumor thrombosis, large tumors, and multiple tumors were significantly associated with positive 18F-FDG PET/CT results. Uptake of 11C-acetate was associated with large and multiple tumors. For 18F-FDG, the sensitivities according to tumor size (1-2, 2-5, and ≥5 cm) were 27.2%, 47.8%, and 92.8%, respectively; for 11C- acetate, these respective values were 31.8%, 78.2%, and 95.2%. 18F-FDG was more sensitive in the detection of poorly differentiated HCC. Overall survival was lower in patients with 18F-FDG PET/CT positive for all indexed lesions than in those with FDG negative or partially positive through the entire follow-up period. In analysis based on biopsied lesions, the sensitivity of 18F-FDG PET/CT was 64.4% for primary HCC and 84.4% for 11C-acetate PET/CT. The overall sensitivities of 18F-FDG, 11C-acetate, and dual-tracer PET/CT for 35 metastatic HCCs were 85.7%, 77.0%, and 85.7%, respectively. There was no significant difference in the sensitivity of tracers according to metastatic tumor size, location, or differentiation. Conclusion: The addition of 11C-acetate to 18F-FDG PET/CT increases the overall sensitivity for the detection of primary HCC but not for the detection of extrahepatic metastases. 18F-FDG, 11C-acetate, and dual-tracer PET/CT have a low sensitivity for the detection of small primary HCC, but 18F-FDG PET/CT has a relatively high sensitivity for the detection of extrahepatic metastases of HCC. Copyright © 2008 by the Society of Nuclear Medicine, Inc.
Files in This Item
There are no files associated with this item.
Appears in
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles


Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Ji Hoon photo

Kim, Ji Hoon
구로병원 (Department of Gastroenterology and Hepatology, Guro Hospital)
Read more


Total Views & Downloads