Detailed Information

Cited 18 time in webofscience Cited 23 time in scopus
Metadata Downloads

Association study between antipsychotics-induced restless legs syndrome and polymorphisms of dopamine D1, D2, D3, and D4 receptor genes in schizophrenia

Authors
Kang, Seung-GulLee, Heon-JeongChoi, Jung-EunPark, Young-MinPark, Jeong-HyunHan, ChangsuKim, Yong-KuKim, Seung-HyunLee, Min-SooJoe, Sook-HaengJung, In-KwaKim, Leen
Issue Date
2008
Publisher
KARGER
Keywords
restless legs syndrome; antipsychotics; schizophrenia; dopamine receptor genes, polymorphism
Citation
NEUROPSYCHOBIOLOGY, v.57, no.1-2, pp.49 - 54
Indexed
SCIE
SCOPUS
Journal Title
NEUROPSYCHOBIOLOGY
Volume
57
Number
1-2
Start Page
49
End Page
54
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17505
DOI
10.1159/000129667
ISSN
0302-282X
Abstract
Objective: The cause of restless legs syndrome (RLS) is not yet clear, but more promising theories involve dopaminergic deficiency and genetic causes. This study investigated whether single-nucleotide polymorphisms in the genes of dopamine receptors DRD1, DRD2, DRD3 and DRD4 are associated with antipsychotics-induced RLS in schizophrenia. Methods: We evaluated 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group and its rating scale for RLS. Genotyping was performed for the DRD1 gene-48A/G, DRD2 gene TaqI A, DRD3 gene Ser9Gly and DRD4 gene -521C/T single-nucleotide polymorphisms. The method of multifactor dimensionality reduction was used to analyze gene-gene interactions. Results: We classified the schizophrenic patients into 96 with and 94 without RLS symptoms. The genotype frequencies of all polymorphisms investigated did not differ significantly between these 2 groups. MDR analysis did not show a significant effect of the 4 dopamine receptor gene variants on susceptibility to antipsychotic-induced RLS symptoms (p > 0.05). Conclusions: These genetics data suggest that the analyzed polymorphisms of the dopamine genes may not be associated with RLS symptoms in schizophrenia. Confirming the results reported here requires a larger-scale study involving patients taking specific antipsychotics. Copyright (c) 2008 S. Karger AG, Basel.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Psychiatry > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Yong Ku photo

Kim, Yong Ku
안산병원 (Department of Psychiatry, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE