Association study between antipsychotics-induced restless legs syndrome and polymorphisms of dopamine D1, D2, D3, and D4 receptor genes in schizophrenia
DC Field | Value | Language |
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dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Choi, Jung-Eun | - |
dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Park, Jeong-Hyun | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Kim, Seung-Hyun | - |
dc.contributor.author | Lee, Min-Soo | - |
dc.contributor.author | Joe, Sook-Haeng | - |
dc.contributor.author | Jung, In-Kwa | - |
dc.contributor.author | Kim, Leen | - |
dc.date.available | 2020-11-03T11:44:53Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0302-282X | - |
dc.identifier.issn | 1423-0224 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17505 | - |
dc.description.abstract | Objective: The cause of restless legs syndrome (RLS) is not yet clear, but more promising theories involve dopaminergic deficiency and genetic causes. This study investigated whether single-nucleotide polymorphisms in the genes of dopamine receptors DRD1, DRD2, DRD3 and DRD4 are associated with antipsychotics-induced RLS in schizophrenia. Methods: We evaluated 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group and its rating scale for RLS. Genotyping was performed for the DRD1 gene-48A/G, DRD2 gene TaqI A, DRD3 gene Ser9Gly and DRD4 gene -521C/T single-nucleotide polymorphisms. The method of multifactor dimensionality reduction was used to analyze gene-gene interactions. Results: We classified the schizophrenic patients into 96 with and 94 without RLS symptoms. The genotype frequencies of all polymorphisms investigated did not differ significantly between these 2 groups. MDR analysis did not show a significant effect of the 4 dopamine receptor gene variants on susceptibility to antipsychotic-induced RLS symptoms (p > 0.05). Conclusions: These genetics data suggest that the analyzed polymorphisms of the dopamine genes may not be associated with RLS symptoms in schizophrenia. Confirming the results reported here requires a larger-scale study involving patients taking specific antipsychotics. Copyright (c) 2008 S. Karger AG, Basel. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | Association study between antipsychotics-induced restless legs syndrome and polymorphisms of dopamine D1, D2, D3, and D4 receptor genes in schizophrenia | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1159/000129667 | - |
dc.identifier.scopusid | 2-s2.0-45549088015 | - |
dc.identifier.wosid | 000257134900011 | - |
dc.identifier.bibliographicCitation | NEUROPSYCHOBIOLOGY, v.57, no.1-2, pp 49 - 54 | - |
dc.citation.title | NEUROPSYCHOBIOLOGY | - |
dc.citation.volume | 57 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 54 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalResearchArea | Psychology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychology | - |
dc.subject.keywordPlus | MULTIFACTOR DIMENSIONALITY REDUCTION | - |
dc.subject.keywordPlus | RATING-SCALE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY LOCUS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | LINKAGE | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordAuthor | restless legs syndrome | - |
dc.subject.keywordAuthor | antipsychotics | - |
dc.subject.keywordAuthor | schizophrenia | - |
dc.subject.keywordAuthor | dopamine receptor genes, polymorphism | - |
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