Comparison of effects of telmisartan and valsartan on late lumen loss and inflammatory markers after sirolimus-eluting stent implantation in hypertensive patients
- Authors
- Hong, Soon Jun; Shim, Wan Joo; Choi, Jong; Joo, Hyung Joon; Shin, Seung Yong; Park, Seong Mi; Lim, Sang Yup; Lim, Do-Sun
- Issue Date
- Dec-2007
- Publisher
- Excerpta Medica, Inc.
- Citation
- American Journal of Cardiology, v.100, no.11, pp 1625 - 1629
- Pages
- 5
- Indexed
- SCOPUS
- Journal Title
- American Journal of Cardiology
- Volume
- 100
- Number
- 11
- Start Page
- 1625
- End Page
- 1629
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17551
- DOI
- 10.1016/j.amjcard.2007.06.068
- ISSN
- 0002-9149
1879-1913
- Abstract
- We compared the effects of telmisartan and valsartan on late lumen loss and inflammatory markers after sirolimus-eluting stent implantation in hypertensive patients. This was a prospective, randomized, single-blinded, 8-month follow-up study that included hypertensive patients with significant coronary artery stenosis treated with telmisartan (n = 79),or valsartan (n = 80). Risk factors such as diabetes, hyperlipidemia, smoking, and obesity were similar between groups. After 8 months of follow-up, only the telmisartan group showed significant decreases in interleukin-6 and tumor necrosis factor-alpha. The decreases from baseline level in total cholesterol and low-density lipoprotein cholesterol concentrations were significantly greater in the telmisartan group. The increase in adiponectin concentrations from baseline measurements was significantly greater in the telmisartan group than in the valsartan group (1.9 +/- 2.7 vs 0.4 +/- 2.0 mu g/ml, respectively, p < 0.05). Moreover, late lumen loss was significantly lower in the telmisartan group than in the valsartan group (0.1 +/- 0.4 vs 0.3 +/- 0.5 mm, respectively, p = 0.001). Major adverse cardiac events were similar between groups. In conclusion, compared with valsartan, telmisartan was associated with a significant decrease in later lumen loss and inflammatory markers after sirolimus-eluting stent implantation in hypertensive patients with significant coronary narrowing. (c) 2007 Elsevier Inc. All rights reserved.
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Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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