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Cited 47 time in webofscience Cited 53 time in scopus
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The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer

Authors
Kwak, Jung-MyunMin, Byung-WookLee, Ju-HanChoi, Jong-SangLee, Sun-IlPark, Sung-SooKim, JinUm, Jun-WonKim, Seon-HanMoon, Hong-Young
Issue Date
Nov-2007
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
colorectal cancer; E-cadherin; liver intestine-cadherin; immunohistochemistry; overall survival; potential marker
Citation
DISEASES OF THE COLON & RECTUM, v.50, no.11, pp.1873 - 1880
Indexed
SCIE
SCOPUS
Journal Title
DISEASES OF THE COLON & RECTUM
Volume
50
Number
11
Start Page
1873
End Page
1880
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17647
DOI
10.1007/s10350-007-9034-1
ISSN
0012-3706
Abstract
Purpose: The significance of liver intestine-cadherin as a potential marker has been growing in the field of oncology, because of its unique features compared with classic cadherins. We investigated the coexpression patterns of E-cadherin and liver intestine-cadherin in colorectal cancer, and determined whether differences in expression patterns were associated with clinicopathologic parameters and also which relationship between these two adhesion molecules existed in colorectal cancer. Methods: Expression pattern of E-cadherin and liver intestine-cadherin was investigated immunohistochemically in 207 colorectal cancers along with clinicopathologic parameters. Results: Reduced expression of liver intestine-cadherin was detected in 51 percent (n=105) of tumors. Such expression was found to be associated with tumoral dedifferentiation (P=0.015) and in a multivariate analysis was associated with a significant worse overall survival after adjustment for tumor stage, differentiation, and E-cadherin status (hazard ratio, 1.951; 95 percent confidence interval, 1.06-3.592; P=0.032). Fifteen percent (n=32) of tumors showed reduced expression of E-cadherin and had relationship with tumoral dedifferentiation (P < 0.001), lymph node metastasis (P=0.004), and advanced stage (P=0.029). Reduced expression of E-cadherin was associated with short overall survival (P=0.028); however, in a multivariate analysis, it was not statistically significant. Conclusions: Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in this series. In addition, early and frequent loss of liver intestine-cadherin expression might be a more sensitive indicator than E-cadherin to predict more aggressive tumoral behavior.
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2. Clinical Science > Department of Foregut Surgery > 1. Journal Articles
1. Basic Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles

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Park, Sungsoo
안암병원 (Department of Foregut Surgery, Anam Hospital)
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