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Cited 37 time in webofscience Cited 37 time in scopus
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Cutaneous silent period in patients with restless leg syndrome

Authors
Han, Jin-KyuOh, KyungmiKim, Byung-JoKoh, Seong-BeomKim, Ju-YeonPark, Kun-WooLee, Dae-Hie
Issue Date
Aug-2007
Publisher
ELSEVIER IRELAND LTD
Keywords
restless leg syndrome; small fiber neuropathy; cutaneous silent period; dopamine agonist
Citation
CLINICAL NEUROPHYSIOLOGY, v.118, no.8, pp 1705 - 1710
Pages
6
Indexed
SCIE
SCOPUS
Journal Title
CLINICAL NEUROPHYSIOLOGY
Volume
118
Number
8
Start Page
1705
End Page
1710
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17828
DOI
10.1016/j.clinph.2007.04.024
ISSN
1388-2457
1872-8952
Abstract
Objective: To investigate the pathophysiological relationship between RLS and small fiber neuropathy using the cutaneous silent period (CSP), which is a spinal reflex mediated by A delta cutaneous afferents and is useful for the evaluation of small-diameter nerve function. Methods: The CSP was measured from the extensor digitorum brevis in 157 patients with RLS and 60 healthy controls. The CSP measurement was repeated in the RLS patients after dopamine agonist treatment for one month. The RLS rating scale for clinical severity was used to evaluate each patient before and after treatment. The measured CSP variables were compared between the patient group and the control group. In addition, the possible correlation between the CSP variables and the RLS rating scale score related to treatment was analyzed. Results: The mean CSP latencies did not differ between the RLS patients and the healthy controls; however, the mean CSP duration was significantly longer in the RLS patients than in the controls, and this prolonged CSP duration improved to the level of the control subjects after dopamine agonist treatment (p = 0.003). The mean RLS rating scale score also significantly decreased after medication (p = 0.000). However, the changes in the CSP variables did not correlate with the decrement in the RLS rating scale score. Conclusions: Although our results do not support the role of A delta fiber dysfunction in RLS, the observed change in CSP duration may be useful as a clinical measure of the improvement with dopamine agonist treatment in patients with RLS. Significance: Further study is needed to elucidate the exact mechanism involved in the prolonged CSP duration in response to treatment. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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Kim, Byung-Jo
Anam Hospital (Department of Neurology, Anam Hospital)
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