A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men
- Authors
- Jo, Sangmee Ahn; Kim, Eun-Kyung; Park, Moon Ho; Han, Changsu; Park, Hyun-Young; Jang, Yangsoo; Song, Byung Joon; Jo, Inho
- Issue Date
- Jul-2007
- Publisher
- ELSEVIER
- Keywords
- aldehyde dehydrogenase 2; polymorphism; myocardial infarction; Koreans
- Citation
- CLINICA CHIMICA ACTA, v.382, no.1-2, pp 43 - 47
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICA CHIMICA ACTA
- Volume
- 382
- Number
- 1-2
- Start Page
- 43
- End Page
- 47
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17877
- DOI
- 10.1016/j.cca.2007.03.016
- ISSN
- 0009-8981
1873-3492
- Abstract
- Background: A homozygous mutant (ALDH2*2/*2) of the gene for mitochondrial aldehyde dehydrogenase 2 (ALDH2) at codon 487 was reported to be associated with myocardial infarction (MI) among Japanese men. However, such an association has never been studied in a Korean population. Method: The subjects consisted of 122 men (60-81 y) with MI recruited randomly from Yonsei University Medical Center, Korea. A total of 439 men (60-84 y) without MI were selected as controls from the Ansan Geriatric Study. ALDH2 genotypes were determined using the TaqMan fluorogenic 5' nuclease polymerase chain reaction assay. Results: Genotypes carrying the mutant ALDH2 allele (ALDH2*1/*2 plus ALDH2*2/*2) were significantly more frequent in patients with MI than in the controls (42.6% vs. 30.5%, P=0.0163). Multiple logistic regression analysis revealed that ALDH2*1/*2 plus ALDH2*2/*2, together with abnormal high density lipoprotein cholesterol and elevated body mass index, was an independent risk factor for MI in elderly Korean men (odds ratio = 1.976, 95% CI: 1.202-3.248). Conclusions: ALDH2 polymorphisms may play an important role in the pathogenesis of MI in elderly Korean men. (c) 2007 Published by Elsevier B.V.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
- 2. Clinical Science > Department of Neurology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.