Cytokine imbalance in the pathophysiology of major depressive disorder
- Authors
- Kim, Yong-Ku; Na, Kyeong-Sae; Shin, Kyung-Ho; Jung, Han-Yong; Choi, So-Hyun; Kim, Jung-Bum
- Issue Date
- 30-Jun-2007
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- antidepressants; cytokines; interleukins; interferons; psychoimmunology; transforming growth factors
- Citation
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.31, no.5, pp 1044 - 1053
- Pages
- 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Volume
- 31
- Number
- 5
- Start Page
- 1044
- End Page
- 1053
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17887
- DOI
- 10.1016/j.pnpbp.2007.03.004
- ISSN
- 0278-5846
1878-4216
- Abstract
- Objective: A substantial body of evidence indicates that dysregulation of the immune system is associated with Major Depressive Disorder (MDD). Because most cytokines have pleiotropic effects, we measured various subsets of cytokines to examine the association between immune response and MDD. Methods: Forty-eight hospitalized MDD patients and 63 normal controls were recruited. We measured in vitro monocytic (IL-6 and tumor necrosis factor (TNF)-alpha), Th1 (interferon (IFN)-gamma and interleukin (IL)-2), Th2 (IL-4), and Treg (transforming growth factor (TGF)-betal) cytokine production as well as IL-2/IL-4 and IFN-gamma/IL-4 ratios for both groups. Depressive symptoms were assessed by Hamilton Depression Rating Scale. Patients were evaluated before and after 6 weeks of antidepressant treatment. Results: At admission, IL-6, TNF-alpha, TGF-betal production, and IFN-gamma/IL-4 ratio were significantly higher, whereas IFN-gamma, IL-2, and IL-4 were significantly lower in MDD patients. After treatment, IL-6 and TGF-betal production were significantly lower than before treatment. Conclusion: We suggest that activation of monocytic proinflammatory cytokines, and inhibition of both Th1 and Th2 cytokines may be associated with immunological dysregulation in MDD. TGF-betal may be associated with the regulation of monocytic cytokines as well as Th1 and Th2 cytokines in MDD. (c) 2007 Elsevier Inc. All rights reserved.
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- Appears in
Collections - 1. Basic Science > Department of Pharmacology > 1. Journal Articles
- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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