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Cited 14 time in webofscience Cited 21 time in scopus
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Combination chemotherapy with bortezomib, cyclophosphamide and dexamethasone may be effective for plasma cell leukemia

Authors
Kim, Seok JinKim, JeeyongCho, YunjungSeo, Bo KyoungKim, Byung Soo
Issue Date
May-2007
Publisher
OXFORD UNIV PRESS
Keywords
bortezomib; cyclophosphamide; plasma cell leukemia; multiple myeloma
Citation
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, v.37, no.5, pp 382 - 384
Pages
3
Indexed
SCIE
SCOPUS
Journal Title
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Volume
37
Number
5
Start Page
382
End Page
384
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17969
DOI
10.1093/jjco/hym037
ISSN
0368-2811
1465-3621
Abstract
Plasma cell leukemia is a rare malignant plasma cell disorder characterized by proliferation of plasma cells in blood and the bone marrow, the outcome of which is poor with conventional therapy. More effective treatment strategies are therefore needed for this disorder. Here, we report a case of secondary plasma cell leukemia from Immunoglobulin D multiple myeloma refractory to doxorubicin-containing chemotherapy and thalidomide. The patient achieved complete remission with bortezomib-containing chemotherapy as follows: bortezomib 1.3 mg/m(2) intravenous infusion on days 1, 4, 8 and 11; cyclophosphamide 750 Mg/M-2 intravenous infusion on days 1 and 3; dexamethasone 40 mg/m(2) intravenous infusion on days 1-4. Complete remission was maintained until the fourth course of the treatment, and we then performed autologous peripheral blood stem cell transplantation. Our experience suggests that combination chemotherapy with bortezomib, cyclophosphamide and dexamethasone may be an effective induction treatment for plasma cell leukemia.
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2. Clinical Science > Department of Radiology > 1. Journal Articles
2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles

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Seo, Bo Kyoung
Ansan Hospital (Department of Radiology, Ansan Hospital)
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