Detailed Information

Cited 18 time in webofscience Cited 18 time in scopus
Metadata Downloads

Combination therapy of vitamin C and thiamine for septic shock in a multicentre, double-blind, randomized, controlled study (ATESS): study protocol for a randomized controlled trialopen access

Authors
Hwang, Sung YeonPark, Jong EunJo, Ik JoonKim, SeonwooChung, Sung PhilKong, TaeyoungShin, JonghwanLee, Hui JaiYou, Kyoung MinJo, You HwanKim, DoyunSuh, Gil JoonKim, TaegyunKim, Won YoungKim, Youn-JungRyoo, Seung MokChoi, Sung-HyukShin, Tae Gun
Issue Date
Jul-2019
Publisher
BioMed Central
Keywords
Sepsis; Septic shock; Thiamine; Vitamin C; Resuscitation
Citation
Trials, v.20
Indexed
SCIE
SCOPUS
Journal Title
Trials
Volume
20
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1807
DOI
10.1186/s13063-019-3542-x
ISSN
1745-6215
Abstract
Background: Septic shock is a life-threatening condition with underlying circulatory and cellular/metabolic abnormalities. Vitamin C and thiamine are potential candidates for adjunctive therapy; they are expected to improve outcomes based on recent experimental and clinical research. The aim of the Ascorbic Acid and Thiamine Effect in Septic Shock (ATESS) trial is to evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients with septic shock. Methods: This study is a randomized, double-blind, placebo-controlled, multicentre trial in adult patients with septic shock recruited from six emergency departments in South Korea. Patients will be randomly allocated into the treatment or control group (1:1 ratio), and we will recruit 116 septic shock patients (58 per group). For the treatment group, vitamin C (50mg/kg) and thiamine (200mg) will be mixed in 50ml of 0.9% saline and administered intravenously every 12h for a total of 48h. For the placebo group, an identical volume of 0.9% saline will be administered in the same manner. The primary outcome is the delta Sequential Organ Failure Assessment (SOFA) score (Delta SOFA=initial SOFA at enrolment - follow-up SOFA after 72h). Discussion: This trial will provide valuable evidence about the effectiveness of vitamin C and thiamine therapy for septic shock. If effective, this therapy might improve survival and become one of the main therapeutic adjuncts for patients with septic shock.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Emergency Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, Sung Hyuk photo

Choi, Sung Hyuk
Guro Hospital (Department of Emergency Medicine, Guro Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE