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Pharmacologic treatment of acute kidney injury: Why drugs haven't worked and what is on the horizon

Authors
Jo S.K.Rosner M.H.Okusa M.D.
Issue Date
2007
Citation
Clinical Journal of the American Society of Nephrology, v.2, no.2, pp.356 - 365
Indexed
SCOPUS
Journal Title
Clinical Journal of the American Society of Nephrology
Volume
2
Number
2
Start Page
356
End Page
365
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18418
DOI
10.2215/CJN.03280906
ISSN
1555-9041
Abstract
Current strategies to limit the extent of injury in acute renal failure are based on extensive studies that identified cellular and molecular mechanisms of acute kidney injury. Despite successes in various animal models, translation to human studies has failed or studies are inconclusive. This review describes past failures and barriers to successful clinical trials. It also focuses on promising preclinical studies using novel compounds that currently are in or close to human investigation. Implementation of previous or novel compounds in well-designed clinical trials provides hope for the successful treatment of this devastating disorder. Copyright © 2007 by the American Society of Nephrology.
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Jo, Sang Kyung
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
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