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Cited 32 time in webofscience Cited 35 time in scopus
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Correlations between umbilical and maternal serum resistin levels and neonatal birth weight

Authors
Cho, Geum JoonYoo, Sang WookHong, Soon CheolOh, Min-JeongKim, TakKim, Hai JoongLee, Kyu WanKim, Sun Haeng
Issue Date
Sep-2006
Publisher
WILEY
Keywords
umbilical cord resistin; neonatal birth weight
Citation
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, v.85, no.9, pp 1051 - 1056
Pages
6
Indexed
SCIE
SCOPUS
Journal Title
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
Volume
85
Number
9
Start Page
1051
End Page
1056
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18689
DOI
10.1080/00016340500470150
ISSN
0001-6349
1600-0412
Abstract
Objective. Resistin is a novel hormone secreted by human adipocytes and mononuclear cells. It is expressed in the human placenta, and has been postulated to play a role in the regulation of energy metabolism during pregnancy. However, correlations between umbilical and maternal serum resistin levels and neonatal birth weight remain poorly understood. The purpose of the study was to clarify the correlation between umbilical and maternal serum resistin levels and neonatal birth weight. Materials and methods. This study included 37 healthy mothers, and their neonates. Resistin levels were determined by ELISA, and compared for correlation between umbilical cord and maternal serum resistin levels and neonatal birth weight. Results. The ranges of resistin levels for umbilical and maternal sera were 10.61-40.81 and 1.14-25.54 ng/ml, respectively. Mean umbilical serum resistin level (21.34 +/- 1.07 ng/ml) was significantly higher than maternal serum resistin level (10.13 +/- 1.12) (p < 0.001). Umbilical serum resistin levels were positively correlated with maternal serum resistin levels (r = 0.607, p , 0.001) and negatively with neonatal birth weight (r = -0.345, p = 0.037). No significant differences in resistin levels were discovered between the female and male neonates. In addition, there were no correlations between the umbilical resistin levels and maternal body mass indices, umbilical leptin levels, or insulin levels. Conclusions. It is suggested that resistin not only affects energy homeostasis by existing in high levels in the fetus, but may play an important role in controlling body weight through effective regulation of adipogenesis by negative feedback.
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Oh, Min Jeong
Guro Hospital (Department of Obstetrics and Gynecology, Guro Hospital)
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