Anti-apoptotic function of thymosin-beta in developing chick spinal motoneurons
- Authors
- Choi, So Yoen; Kim, Dong Ki; Eun, Bokkee; Kim, Kyungjin; Sun, Woong; Kim, Hyun
- Issue Date
- 4-Aug-2006
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- thymosin-beta; motoneuron; programmed cell death; Jun; chick embryo
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.346, no.3, pp 872 - 878
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 346
- Number
- 3
- Start Page
- 872
- End Page
- 878
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18695
- DOI
- 10.1016/j.bbrc.2006.05.207
- ISSN
- 0006-291X
1090-2104
- Abstract
- Thymosin-beta s (T beta s) are water-soluble peptides abundantly present in the cytoplasm and extracellular compartment. The functions of T beta s appear to be pleiotrophic, including actin-remodeling, wound healing, angiogenesis, etc. In the present study, we present the evidence that T beta s have anti-apoptotic activity on developing chick motoneurons (MNs) in vivo. Using in ovo electroporation, we introduced three isoforms of T beta (T beta 4, T beta 10, and T beta 15) and found the significantly diminished normal and limb bud removal (LBR)-induced programmed cell death. Such anti-apoptotic activity is independent of T beta's actin remodeling activity. On the other hand, overexpression of T beta s substantially reduced early cell death initiation signal, such as phosphorylation of c-Jun. Collectively, these results suggest that T beta s may prevent apoptosis of neurons via blockade of early apoptogenic signals independent of actin remodeling action. (c) 2006 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 1. Basic Science > Department of Anatomy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.