Comparison of the effects of nicorandil and cocktail solution to prevent radial artery spasm during coronary angiography
- Authors
- Kim S.H.; Kim E.J.; Kim M.K.; Yun I.S.; Park W.J.; Han S.J.; Cho G.Y.; Choi Y.J.; Hong K.S.; Han K.R.; Oh D.J.; Rhim C.Y.
- Issue Date
- 2006
- Publisher
- Korean Society of Circulation
- Keywords
- Coronary angiography; Nicorandil; Radial artery; Spasm
- Citation
- Korean Circulation Journal, v.36, no.2, pp 133 - 139
- Pages
- 7
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Circulation Journal
- Volume
- 36
- Number
- 2
- Start Page
- 133
- End Page
- 139
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19271
- DOI
- 10.4070/kcj.2006.36.2.133
- ISSN
- 1738-5520
1738-5555
- Abstract
- Background and Objectives: A radial artery spasm is one of the most common complications of coronary angiography during a transradial, causing considerable patient discomfort, which sometimes disturbs the procedure. This study was designed to evaluate the effects of nicorandil in the prevention of a radial artery spasm during coronary angiography. Subjects and Methods: This was a randomized study to compare 4 mg of nicorandil and a 10 mL cocktail solution performed in 100 patients. Vasospasms of the radial artery, which were expressed as stenosis of the vessel diameter with a transradial approach and radial artery patency by pulse oximetry analysis one month later, were examined. Results: Reductions in the systolic and diastolic blood pressures after administration of the spasmolytic agents were 15.8 ± 11.8/8.4 ± 8.0 and 20.5 ± 13.6/6.7 ± 6.2 in the for nicorandil and cocktail groups, respectively. Nicorandil induced a lesser decrease in the systolic BP than the cocktail, but without statistical significance (p = 0.07). Both vasodilating agents showed a significant radial artery vasodilation following their intra-arterial administration (p < 0.001 for all). The diameter of the radial artery showed a significant decrease in both groups following catheterization (p < 0.05 for all). There were no significant differences between the two groups in terms of radial artery spasms (46 vs. 58% in nicorandil and cocktail groups, respectively, p = 0.709). Conclusion: Nicorandil, with vasodilatory effects due to a dual mechanism was as effective as the cocktail solution in the vasodilation of the radial artery. © 2006, The Korean Society of Circulation.
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Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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