Increased plasma nitric oxide metabolites in suicide attempters
- Authors
- Lee, Bun-Hee; Lee, Sung-Woo; Yoon, Dokyung; Lee, Heon-Jeong; Yang, Jong-Chul; Shim, Se-Hoon; Kim, Do-Hoon; Ryu, Seung-Ho; Han, Changsu; Kim, Yong-Ku
- Issue Date
- 2006
- Publisher
- KARGER
- Keywords
- suicide; nitric oxide; risk-rescue rating scale; depression; bipolar disorder; schizophrenia
- Citation
- NEUROPSYCHOBIOLOGY, v.53, no.3, pp 127 - 132
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROPSYCHOBIOLOGY
- Volume
- 53
- Number
- 3
- Start Page
- 127
- End Page
- 132
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19337
- DOI
- 10.1159/000092542
- ISSN
- 0302-282X
1423-0224
- Abstract
- Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NOx) and suicide attempt. Method: Plasma NOx levels were measured in 53 patients who had recently attempted suicide, 58 nonsuicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. Results: Plasma. NOx levels were significantly higher in suicidal patients than nonsuicidal psychiatric patients or normal control subjects (F = 11.029, d.f. = 2, 183, p < 0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NOx levels than nonsuicidal depressive patients (t = -3.090, d.f. = 84, p = 0.003). Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients. Copyright (c) 2006 S. Karger AG, Basel.
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- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
- 2. Clinical Science > Department of Family Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Emergency Medicine > 1. Journal Articles
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