Detailed Information

Cited 23 time in webofscience Cited 25 time in scopus
Metadata Downloads

Long-term safety and effectiveness of growth hormone therapy in Korean children with growth disorders: 5-year results of LG Growth Studyopen access

Authors
Rhie, Young-JunYoo, Jae-HoChoi, Jin-HoChae, Hyun-WookKim, Jae HyunChung, SochungHwang, Il TaeShin, Choong HoKim, Eun YoungKim, Ho-Seong
Issue Date
16-May-2019
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.14, no.5
Indexed
SCIE
SCOPUS
Journal Title
PLOS ONE
Volume
14
Number
5
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2026
DOI
10.1371/journal.pone.0216927
ISSN
1932-6203
Abstract
Purpose The aim of this registry study was to analyze the long-term safety and effectiveness of recombinant human growth hormone (rhGH) in South Korean pediatric patients (>= 2 years of age) with growth hormone deficiency GHD) of idiopathic or organic etiology, idiopathic short stature, Turner syndrome, small for gestational age and chronic renal failure. Methods The study patients were followed-up till two years after the epiphyseal closure, with visits scheduled every six months. The outcome measures included the incidence of adverse events (AEs, in particular, neoplasia, glucose intolerance and hypothyroidism), as well as height standard deviation score (Ht SDS) and annual height velocity. The results of the interim analysis of a 5-year accumulated data for 2,024 patients (7,342 patient-years, PY) are presented. Results A total of 14 neoplasms were diagnosed (191/100,000 PY); 7 out of 9 malignancies were recurrent craniopharyngioma found in patients with organic GHD. Seven cases of glucose intolerance (95/100,000 PY) and 22 cases of hypothyroidism (300/100,000 PY) were detected; about half of the cases (4 and 10 cases each) were considered to be related with rhGH treatment. Most of the growth-retarded patients showed continuous improvement in Ht SDS, with the most prominent effect observed within a year of treatment initiation. The beneficial effect of rhGH on Ht SDS gain was maintained for 2-4 years. Conclusions The incidence of AEs of interest in rhGH-treated patients was low, and most of the neoplasms were benign and/or non-related to rhGH. Most patients benefited from the therapy in terms of height increment.
Files in This Item
Appears in
Collections
2. Clinical Science > Department of Pediatrics > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Rhie, Young Jun photo

Rhie, Young Jun
Ansan Hospital (Department of Pediatrics, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE