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Cited 20 time in webofscience Cited 22 time in scopus
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Proton pump inhibitor: The dual role in gastric cancer

Authors
Joo, Moon KyungPark, Jong JaeChun, Hoon Jai
Issue Date
May-2019
Publisher
Baishideng Publishing Group
Keywords
Proton pump inhibitor; Gastric cancer; Drug resistance; Signal transducer and activator of transcription 3
Citation
World Journal of Gastroenterology, v.25, no.17, pp.2058 - 2070
Indexed
SCIE
SCOPUS
Journal Title
World Journal of Gastroenterology
Volume
25
Number
17
Start Page
2058
End Page
2070
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2034
DOI
10.3748/wjg.v25.i17.2058
ISSN
1007-9327
Abstract
Proton pump inhibitors (PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicohacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile, several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer sternness and signal transducer and activator of transcription 3 (STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may "play dual role" in gastric carcinogenesis and treatment of gastric cancer.
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Chun, Hoon Jai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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