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Cited 27 time in webofscience Cited 27 time in scopus
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Proton pump inhibitor: The dual role in gastric cancer

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dc.contributor.authorJoo, Moon Kyung-
dc.contributor.authorPark, Jong Jae-
dc.contributor.authorChun, Hoon Jai-
dc.date.available2020-11-02T06:35:50Z-
dc.date.issued2019-05-
dc.identifier.issn1007-9327-
dc.identifier.issn2219-2840-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2034-
dc.description.abstractProton pump inhibitors (PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicohacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile, several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer sternness and signal transducer and activator of transcription 3 (STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may "play dual role" in gastric carcinogenesis and treatment of gastric cancer.-
dc.format.extent13-
dc.language영어-
dc.language.isoENG-
dc.publisherBaishideng Publishing Group-
dc.titleProton pump inhibitor: The dual role in gastric cancer-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.3748/wjg.v25.i17.2058-
dc.identifier.scopusid2-s2.0-85065887173-
dc.identifier.wosid000466977300004-
dc.identifier.bibliographicCitationWorld Journal of Gastroenterology, v.25, no.17, pp 2058 - 2070-
dc.citation.titleWorld Journal of Gastroenterology-
dc.citation.volume25-
dc.citation.number17-
dc.citation.startPage2058-
dc.citation.endPage2070-
dc.type.docTypeReview-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusHELICOBACTER-PYLORI INFECTION-
dc.subject.keywordPlusACID-SUPPRESSIVE DRUGS-
dc.subject.keywordPlusLYMPH-NODE METASTASIS-
dc.subject.keywordPlusHEPATOCELLULAR-CARCINOMA-
dc.subject.keywordPlusANTITUMOR-ACTIVITY-
dc.subject.keywordPlusSERUM GASTRIN-
dc.subject.keywordPlusSTEM-CELLS-
dc.subject.keywordPlusPHASE-I-
dc.subject.keywordPlusSTAT3-
dc.subject.keywordPlusRESISTANCE-
dc.subject.keywordAuthorProton pump inhibitor-
dc.subject.keywordAuthorGastric cancer-
dc.subject.keywordAuthorDrug resistance-
dc.subject.keywordAuthorSignal transducer and activator of transcription 3-
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Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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