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Cited 6 time in webofscience Cited 7 time in scopus
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Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation

Authors
Roh, Seung-YoungLee, Dae InHwang, Sung HoLee, Kwang-NoBaek, Yong-sooIqbal, MohammadKim, Dong-HyeokAhn, JinheeShim, JaeminChoi, Jong-IlKim, Young-Hoon
Issue Date
Oct-2020
Publisher
NATURE RESEARCH
Citation
Scientific Reports, v.10, no.1
Indexed
SCIE
SCOPUS
Journal Title
Scientific Reports
Volume
10
Number
1
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2040
DOI
10.1038/s41598-020-72929-0
ISSN
2045-2322
Abstract
Atrial remodeling with fibrosis has been well-described in patients with atrial fibrillation (AF). We hypothesized that the left atrial (LA)-late gadolinium enhancement (LGE) extent on cardiac magnetic resonance (CMR) imaging is associated with LA pressure and can be a marker for suitable candidates for non-paroxysmal AF ablation. A total of 173 AF patients with an LA-LGE area on CMR imaging were enrolled. The clinical parameters, including invasively measured LA pressure, were compared between the patients with extensive LA-LGE (E-LGE, LGE extent >= 20%, n = 78) and those with small LA-LGE (S-LGE, LGE extent < 20%, n = 95). The E-LGE group had higher peak LA pressures than the S-LGE group (23 versus 19 mmHg, p < 0.001). The E-LGE group had more patients with non-paroxysmal AF (non-PAF) ( 51% vs. 34%), heart failure (9% vs. 0%), and higher NT pro-B-type natriuretic peptide (472 vs. 265 pg/ml) (all p < 0.05). LA pressure >= 21 mmHg was an independent predictor of E-LGE (OR = 2.218; p = 0.019). In the paroxysmal AF (PAF) subgroup, freedom from atrial arrhythmia after catheter ablation was not different (81% vs 86%, log-rank p = 0.529). However, in the non-PAF subgroup, it was significantly higher in the S-LGE group than in the E-LGE group (81% vs 55%, log-rank p = 0.014). Increased LA pressure was related to the LA-LGE extent. LA-LGE was a good predictor of outcome after catheter ablation, but only in patients with non-PAF.
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2. Clinical Science > Department of Radiology > 1. Journal Articles
2. Clinical Science > Department of Cardiology > 1. Journal Articles

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Anam Hospital (Department of Cardiology, Anam Hospital)
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