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Cited 9 time in webofscience Cited 11 time in scopus
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N'-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells

Authors
Park, JKChung, YMKim, BGYoo, YAYang, BSKim, JSYoo, YD
Issue Date
Apr-2004
Publisher
AMER ASSOC CANCER RESEARCH
Keywords
CANCER-CELLS; IONIZING-RADIATION; INDUCED APOPTOSIS; P53; KINASE; ACTIVATION; INVOLVEMENT; WORTMANNIN; INHIBITION; RESISTANCE
Citation
MOLECULAR CANCER THERAPEUTICS, v.3, no.4, pp 403 - 407
Pages
5
Indexed
SCIE
SCOPUS
Journal Title
MOLECULAR CANCER THERAPEUTICS
Volume
3
Number
4
Start Page
403
End Page
407
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20564
ISSN
1535-7163
1538-8514
Abstract
To develop a new radiosensitizer, we screened a chemical library and selected one chemical reagent, N'-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester (PHCM), which was already known to have antifungal and antimicrobial properties. PHCM enhanced radiation-induced cell death and its mean calculated dose enhancement ratio was 1.17. PHCM was found to induce the phosphorylation of p38 mitogen-activated protein kinase, and combined treatment with PHCM and radiation down-regulated Bcl-2. In a xenograft assay, the combined PHCM and radiation group showed 39.3 days of growth delay versus the control in terms of tumor growth. The enhancement factor of this combined treatment was determined to be 4.02.
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3. Graduate School > Biomedical Research Center > 1. Journal Articles
2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles

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Kim, Jun Suk
Guro Hospital (Department of Medical Oncology and Hematology, Guro Hospital)
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