미래의 항우울제 : 어떠한 것들이 개발되고 있는가?Recent Development on Future Antidepressants
- Other Titles
- Recent Development on Future Antidepressants
- Authors
- 김용구
- Issue Date
- Jun-2004
- Publisher
- 대한생물정신의학회
- Keywords
- 항우울제; 신경생물학; 단가아민; 사이토카인; 신경펩타이드; 우울증; Antidepressant; Neurobiology; Monoamine; Cytokine; Neuropeptide; Depression.
- Citation
- 생물정신의학, v.11, no.1, pp 14 - 25
- Pages
- 12
- Indexed
- KCICANDI
- Journal Title
- 생물정신의학
- Volume
- 11
- Number
- 1
- Start Page
- 14
- End Page
- 25
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20709
- ISSN
- 1225-8709
- Abstract
- The current understanding of the mechanisms of pharmacotherapy for depression is characterized by an emphasis on increasing synaptic availability of serotonin, noradrenaline, and possibly dopamine, while minimizing side effects. The acute effects of current available effective antidepressants include blocking selective serotonin or noradrenaline reuptake, alpha2 autoreceptors or monoamine oxidase. Although efficacious, current treatments often produce partial or limited symptomatic improvement rather than remission. While current pharmacotherapies target monoaminergic systems, distinct neurobiological underpinnings and other systems are likely involved in the pathogenesis of depression. Recently, several promising hypotheses of depression and antidepressant action have been formulated. These hypotheses are largely based on dsyregulation of neural plasticity, CREB, BDNF, corticotropin-releasing factor, glucocorticoid, hypothalamic-pituitary adrenal axis and cytokines. Based on these new theories and hypotheses of depression, a number of new and novel agents, including corticotropin-releasing factor antagonists, antiglucocorticoids, and substance P antagonists show a considerable promise for refining treatment options for depression. In this article, the current available pharmacotherapies, current understanding of neurobiology and pathogenesis of depression and new and promising directions in pharmacological research on depression will be discussed.
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