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Cited 0 time in webofscience Cited 26 time in scopus
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Micro-MRI methods to detect renal cysts in mice

Authors
Kobayashi H.Kawamoto S.Brechbiel M.W.Jo S.-K.Hu X.Yang T.Diwan B.A.Waldmann T.A.Schnermann J.Choyke P.L.Star R.A.
Issue Date
2004
Publisher
Blackwell Publishing Inc.
Keywords
Chronic kidney disease; COX-2; Cyst; Kidney; Magnetic resonance imaging; Sickle cell disease
Citation
Kidney International, v.65, no.4, pp 1511 - 1516
Pages
6
Indexed
SCOPUS
Journal Title
Kidney International
Volume
65
Number
4
Start Page
1511
End Page
1516
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20849
DOI
10.1111/j.1523-1755.2004.00532.x
ISSN
0085-2538
1523-1755
Abstract
Background. Mouse models of disease, especially using transgenic and knockout technologies, are powerful tools to analyze the molecular basis of disease. We recently reported that a new dynamic micro-MRI method with dendrimer-based contrast agents can visualize renal structure and function in normal living mice and mice with acute renal failure. While MRI contrast enhancement is useful for detecting functional impairment of the kidneys, this technology has limitations in assessing morphologic changes, particularly cystic disease, because contrast-enhanced micro-MRI depicts cysts as low-intensity areas that cannot be distinguished from fibrotic foci. Methods. In the current study, we evaluated if micro-MRI employing a new three-dimensional MR hydrography signal sequence [three-dimensional fast imaging employing steady-state acquisition (3D-FIESTA)] can visualize chronic cystic changes without any contrast agents. Results. We were able to positively depict multiple renal cortical cysts of ∼0.2 mm diameter in a mouse model of sickle cell disease and observe serial changes of renal cysts (>0.2 mm diameter) in cyclooxygenase-2 (COX-2) knockout mice during a 21/2-month period. Some cysts decreased in size over time. Conclusions. Micro-MRI with 3D-FIESTA can depict cyst formation in the diseased kidneys of living mice without injection of contrast agents.
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