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α-fetoprotein impairs APC function and induces their apoptosis

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dc.contributor.authorUm S.H.-
dc.contributor.authorMulhall C.-
dc.contributor.authorAlisa A.-
dc.contributor.authorIves A.R.-
dc.contributor.authorKarani J.-
dc.contributor.authorWilliams R.-
dc.contributor.authorBertoletti A.-
dc.contributor.authorBehboudi S.-
dc.date.available2020-11-03T17:51:55Z-
dc.date.created2020-10-19-
dc.date.issued2004-08-
dc.identifier.issn0022-1767-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20882-
dc.description.abstractα-Fetoprotein (AFP) is a tumor-associated Ag, and its serum level is elevated in patients with hepatocellular carcinoma (HCC). In vitro, AFP induces functional impairment of dendritic cells (DCs). This was demonstrated by the down-regulation of CD40 and CD86 molecnles and the impairment of allostimulatory function. Also, AFP was found to induce significant apoptosis of DCs, and AFP-treated DCs produced low levels of IL-12 and TNF-α, a cytokine pattern that could hamper an efficient antitumor immune response. Ex vivo, APCs of patients with HCC and high levels of AFP produced lower levels of TNF-α than that of healthy individuals. In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control.-
dc.language영어-
dc.language.isoen-
dc.publisherAmerican Association of Immunologists-
dc.titleα-fetoprotein impairs APC function and induces their apoptosis-
dc.typeArticle-
dc.contributor.affiliatedAuthorUm S.H.-
dc.identifier.doi10.4049/jimmunol.173.3.1772-
dc.identifier.scopusid2-s2.0-3242779196-
dc.identifier.bibliographicCitationJournal of Immunology, v.173, no.3, pp.1772 - 1778-
dc.relation.isPartOfJournal of Immunology-
dc.citation.titleJournal of Immunology-
dc.citation.volume173-
dc.citation.number3-
dc.citation.startPage1772-
dc.citation.endPage1778-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusalpha fetoprotein-
dc.subject.keywordPlusB7 antigen-
dc.subject.keywordPlusCD14 antigen-
dc.subject.keywordPlusCD19 antigen-
dc.subject.keywordPlusCD20 antibody-
dc.subject.keywordPlusCD40 antigen-
dc.subject.keywordPlusCD83 antigen-
dc.subject.keywordPlusCD86 antigen-
dc.subject.keywordPluscytokine-
dc.subject.keywordPlusglycoprotein p 15095-
dc.subject.keywordPlusgranulocyte macrophage colony stimulating factor-
dc.subject.keywordPlusHLA DR antigen-
dc.subject.keywordPlusinterleukin 12-
dc.subject.keywordPlusinterleukin 4-
dc.subject.keywordPlust6 antigen-
dc.subject.keywordPlustumor necrosis factor alpha-
dc.subject.keywordPlusalcohol liver cirrhosis-
dc.subject.keywordPlusantigen presenting cell-
dc.subject.keywordPlusapoptosis-
dc.subject.keywordPlusarticle-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPlusdendritic cell-
dc.subject.keywordPlusenzyme immunoassay-
dc.subject.keywordPlusenzyme linked immunosorbent assay-
dc.subject.keywordPlushepatitis B-
dc.subject.keywordPlushepatitis C-
dc.subject.keywordPlushuman-
dc.subject.keywordPlushuman cell-
dc.subject.keywordPlusin vitro study-
dc.subject.keywordPlusliver cell carcinoma-
dc.subject.keywordPluslymphocyte proliferation-
dc.subject.keywordPlusmixed lymphocyte reaction-
dc.subject.keywordPlusmonocyte-
dc.subject.keywordPlusperipheral blood mononuclear cell-
dc.subject.keywordPluspriority journal-
dc.subject.keywordPlustumor immunity-
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