α-fetoprotein impairs APC function and induces their apoptosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Um S.H. | - |
dc.contributor.author | Mulhall C. | - |
dc.contributor.author | Alisa A. | - |
dc.contributor.author | Ives A.R. | - |
dc.contributor.author | Karani J. | - |
dc.contributor.author | Williams R. | - |
dc.contributor.author | Bertoletti A. | - |
dc.contributor.author | Behboudi S. | - |
dc.date.available | 2020-11-03T17:51:55Z | - |
dc.date.issued | 2004-08 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20882 | - |
dc.description.abstract | α-Fetoprotein (AFP) is a tumor-associated Ag, and its serum level is elevated in patients with hepatocellular carcinoma (HCC). In vitro, AFP induces functional impairment of dendritic cells (DCs). This was demonstrated by the down-regulation of CD40 and CD86 molecnles and the impairment of allostimulatory function. Also, AFP was found to induce significant apoptosis of DCs, and AFP-treated DCs produced low levels of IL-12 and TNF-α, a cytokine pattern that could hamper an efficient antitumor immune response. Ex vivo, APCs of patients with HCC and high levels of AFP produced lower levels of TNF-α than that of healthy individuals. In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Association of Immunologists | - |
dc.title | α-fetoprotein impairs APC function and induces their apoptosis | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.4049/jimmunol.173.3.1772 | - |
dc.identifier.scopusid | 2-s2.0-3242779196 | - |
dc.identifier.bibliographicCitation | Journal of Immunology, v.173, no.3, pp 1772 - 1778 | - |
dc.citation.title | Journal of Immunology | - |
dc.citation.volume | 173 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1772 | - |
dc.citation.endPage | 1778 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | alpha fetoprotein | - |
dc.subject.keywordPlus | B7 antigen | - |
dc.subject.keywordPlus | CD14 antigen | - |
dc.subject.keywordPlus | CD19 antigen | - |
dc.subject.keywordPlus | CD20 antibody | - |
dc.subject.keywordPlus | CD40 antigen | - |
dc.subject.keywordPlus | CD83 antigen | - |
dc.subject.keywordPlus | CD86 antigen | - |
dc.subject.keywordPlus | cytokine | - |
dc.subject.keywordPlus | glycoprotein p 15095 | - |
dc.subject.keywordPlus | granulocyte macrophage colony stimulating factor | - |
dc.subject.keywordPlus | HLA DR antigen | - |
dc.subject.keywordPlus | interleukin 12 | - |
dc.subject.keywordPlus | interleukin 4 | - |
dc.subject.keywordPlus | t6 antigen | - |
dc.subject.keywordPlus | tumor necrosis factor alpha | - |
dc.subject.keywordPlus | alcohol liver cirrhosis | - |
dc.subject.keywordPlus | antigen presenting cell | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | dendritic cell | - |
dc.subject.keywordPlus | enzyme immunoassay | - |
dc.subject.keywordPlus | enzyme linked immunosorbent assay | - |
dc.subject.keywordPlus | hepatitis B | - |
dc.subject.keywordPlus | hepatitis C | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | liver cell carcinoma | - |
dc.subject.keywordPlus | lymphocyte proliferation | - |
dc.subject.keywordPlus | mixed lymphocyte reaction | - |
dc.subject.keywordPlus | monocyte | - |
dc.subject.keywordPlus | peripheral blood mononuclear cell | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | tumor immunity | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.