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Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolates from patients with chronic HBV infection in Korea
- Authors
- Odgerel, Zagaa; Nho, Kyung Bo; Moon, Ju Young; Kee, Sun Ho; Park, Kwang Sook; Song, Ki-Joon; Baek, Luck Ju; Yeon, Jong Eun; Byun, Kwan Soo; Lee, Chang Hong; Song, Jin Won
- Issue Date
- Dec-2003
- Publisher
- John Wiley & Sons Inc.
- Keywords
- chronic hepatitis; HBV genotype; phylogeny; polymerase chain reaction
- Citation
- Journal of Medical Virology, v.71, no.4, pp 499 - 503
- Pages
- 5
- Indexed
- SCOPUS
- Journal Title
- Journal of Medical Virology
- Volume
- 71
- Number
- 4
- Start Page
- 499
- End Page
- 503
- ISSN
- 0146-6615
1096-9071
- Abstract
- Although there is a report of high rate of hepatitis B virus (HBV) infection in South Korea, only a few entire genome sequences of HBV isolates from Korea have been reported. To obtain the complete nucleotide sequence of the Korean HBV, viral DNA was extracted from sera of Korean patients with chronic HBV infection who have not been exposed to any antiviral treatment. Complete genomic sequences were determined on three Korean HBV isolates. The entire genomic length of Korean HBV isolates, designated as KUHB84, KUHB81, and KUHB95, was 3,215 base pairs. No deletions and insertions were observed. Core promoter mutations (T1762/A1764) were detected in two isolates, KUHB84 and KUHB95. Phylogenetic analysis based on the entire genomic sequences showed that the Korean HBV isolates were genotype C and related closely to the Japanese HBV. (C) 2003 Wiley-Liss, Inc.
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Related Researcher
- Byun, Kwan Soo
- Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)