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Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian Patients

Authors
Park, Sung ChulJeen, Yoon Tae
Issue Date
May-2019
Publisher
MDPI
Keywords
genetics; inflammatory bowel disease; Crohn' s disease; ulcerative colitis
Citation
CELLS, v.8, no.5
Indexed
SCIE
Journal Title
CELLS
Volume
8
Number
5
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2122
DOI
10.3390/cells8050404
ISSN
2073-4409
Abstract
The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies have identified more than 240 genetic variants related to IBD. These genetic variants are involved in innate and adaptive immunity, autophagy, defective bacterial handing, interleukin-23 and 10 signaling, and so on. According to several epidemiological and clinical studies, the phenotypes and clinical course of IBD differ between Asians and Europeans. Although the risk loci for IBD typically overlap between Asians and Westerners, genetic heterogeneity has been detected in many loci/genes, such as NOD2/CARD15, TNFSF15 and human leukocyte antigen, contributing to the risk of IBD. Thus, although common pathways exist between Westerners and Asians in the development of IBD, their significance may differ for individual pathways. Although genetic studies are not universally applicable in the clinical field, they may be useful for diagnosing and categorizing IBD, predicting therapeutic responses and toxicity to drugs, and assessing prognosis by risk modeling, thereby enabling precision medicine for individual patients.
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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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