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흡연에 있어 도파민 D2 수용체의 다형성Dopamine D2 Receptor Gene Polymorphism in Cigarette Smoking

Other Titles
Dopamine D2 Receptor Gene Polymorphism in Cigarette Smoking
Authors
이홍석송성민이헌정
Issue Date
Mar-2003
Publisher
대한신경정신의학회
Keywords
Heterosis·Smoking·Dopamine D2 receptor·Polymorphism·Gender difference.
Citation
신경정신의학, v.42, no.2, pp 202 - 207
Pages
6
Journal Title
신경정신의학
Volume
42
Number
2
Start Page
202
End Page
207
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/21326
ISSN
1015-4817
2289-0963
Abstract
Objective:This study was to examine the effects of DRD2 TaqI A polymorphism on the smoking in Koreans. Also this study examined molecular heterosis and gender difference in the genetic effect of cigarette smoking. Methods:DRD2 TaqI A RFLP genotyping was carried out with DNA extracted from blood samples of 187 healthy individuals including 94 smokers and 93 non-smokers, Results:Among the total subjects, the smokers were not significantly different from the non-smokers in respect to the frequency and prevalence of A1 allele, the genotype distribution, or the frequency of heterozygotes. Separating the subjects by gender, however, in male subjects smokers showed a significantly higher frequency (p=0.049) and prevalence of A1 allele (p=0.016) than non-smokers. Also, genotype distribution (p=0.055) and frequency of heterozygotes (p=0.058) of smokers showed some different distributions, but there were no significant statistical difference. In contrast, female subjects showed significant difference between smokers and non-smokers in the comparison of frequency of heterozygotes (p=0.018), but not in the comparison of the frequency (p=0.582) and prevalence (p=0.082) of A1 allele and genotype distribution (p=0.060). Conclusion:No significant difference between smokers and non-smokers in the genotype distributions of the total sample could be explained by the reciprocal effects of gender difference in the genetic effect of DRD2 A1 allele of the smoking. Our findings support gender difference and molecular heterosis at the DRD2 gene effects of smoking. (J Korean Neuropsychiatr Assoc 2003;42(2):202-207)
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