흡연에 있어 도파민 D2 수용체의 다형성Dopamine D2 Receptor Gene Polymorphism in Cigarette Smoking
- Other Titles
- Dopamine D2 Receptor Gene Polymorphism in Cigarette Smoking
- 이홍석; 송성민; 이헌정
- Issue Date
- Heterosis·Smoking·Dopamine D2 receptor·Polymorphism·Gender difference.
- 신경정신의학, v.42, no.2, pp.202 - 207
- Journal Title
- Start Page
- End Page
- Objective：This study was to examine the effects of DRD2 TaqI A polymorphism on the smoking in Koreans. Also this study
examined molecular heterosis and gender difference in the genetic effect of cigarette smoking.
Methods：DRD2 TaqI A RFLP genotyping was carried out with DNA extracted from blood samples of 187 healthy individuals including 94 smokers and 93 non-smokers,
Results：Among the total subjects, the smokers were not significantly different from the non-smokers in respect to the
frequency and prevalence of A1 allele, the genotype distribution, or the frequency of heterozygotes. Separating the subjects by
gender, however, in male subjects smokers showed a significantly higher frequency (p=0.049) and prevalence of A1 allele
(p=0.016) than non-smokers. Also, genotype distribution (p=0.055) and frequency of heterozygotes (p=0.058) of smokers
showed some different distributions, but there were no significant statistical difference. In contrast, female subjects showed
significant difference between smokers and non-smokers in the comparison of frequency of heterozygotes (p=0.018), but not
in the comparison of the frequency (p=0.582) and prevalence (p=0.082) of A1 allele and genotype distribution (p=0.060).
Conclusion：No significant difference between smokers and non-smokers in the genotype distributions of the total sample
could be explained by the reciprocal effects of gender difference in the genetic effect of DRD2 A1 allele of the smoking. Our
findings support gender difference and molecular heterosis at the DRD2 gene effects of smoking. (J Korean Neuropsychiatr
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